Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🐁 Led by Ling-Xiao Shao and Clara Liao Funded by NIH National Institute of Mental Health (NIMH) 📄Read in nature - nature.com/articles/s4158… 1/12

Delighted to share our new study, led by @annacgeraghty and Lehi Acosta , uncovering the cellular dysregulation underpinning cognitive impairment after CAR T cell therapy and a strategy to rescue this cellular and cognitive dysfunction in mice. 1/ cell.com/cell/fulltext/…

Have you discovered the Night Science Podcast yet? The Night Science Podcast

Thrilled to share our latest preprint led by the fantastic student Ziyu Ziyu Lu! We constructed a scATAC-seq atlas profiling > 500 mouse tissues to explore cell population dynamics during mammalian aging and the associated chromatin landscape changes: biorxiv.org/content/10.110…

Online now: Myocardium and endocardium of the early mammalian heart tube arise from independent multipotent lineages specified at the primitive streak dlvr.it/TL1Br7

Inducible protein degradation reveals inflammation-dependent function of the Treg cell lineage–defining transcription factor Foxp3 Science Immunology science.org/doi/10.1126/sc…

🧠 Zoning out could be beneficial—and may actually help us learn faster. 🥼 New research led by Lin Zhong Marius Pachitariu & Carsen Stringer @[email protected] janelia.org/news/zoning-ou…

Inflammation, thought to be a driver of age-related disease, does not worsen with age in some Indigenous communities go.nature.com/3ZS9HFG

🚨New paper on theories of ageing I discuss the major mechanistic theories of ageing in light of recent findings as well as the fundamental nature of the ageing process. Theoretical work is more important than ever in biology, including in ageing. nature.com/articles/s4155…

Nonuniversality of inflammaging across human populations nature.com/articles/s4358…

"Here we present the first direct evidence that H3K4me3 is not a cause but a consequence of transcriptional activation, functioning as a downstream epigenetic response" biorxiv.org/content/10.110…

Challenging a longevity dogma in muscle aging. Validated epigenetic clocks (pan-mammalian and muscle-specific) reveal a surprise: an 85% drop in NAD⁺ in mouse muscle leaves epigenetic age unchanged. Muscle structure, function, and mitochondria stay strong: NAD⁺ loss ≠ muscle

A study in nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4obcunE

Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures biorxiv.org/content/10.110… #biorxiv_immuno

Our work using cell-free RNA as a minimally invasive bioanalyte to investigate circulating biomarkers and the pathobiology of ME/CFS is out today in PNASNews! Led by Iwijn De Vlaminck, Maureen Hanson, and Cornell Center for Enervating NeuroImmune Disease #cfRNA #MECFS #PNAS pnas.org/doi/10.1073/pn…

Excited to share our urine cell-free RNA (cfRNA) study, now out in Clinical Chemistry Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications academic.oup.com/clinchem/artic…

Brilliant idea with big impact! Must read🧬 Amazing work!! Congratulations Alexandre Pellan Cheng!!! 👏👏

RESTRICT-seq enables time-gated CRISPR screens and uncovers novel epigenetic dependencies of SCC resistance biorxiv.org/content/10.110… #biorxiv_cancer

CRISPR screens revolutionized genetics; but what if the method itself introduces noise? 🤔 📣We developed RESTRICT-seq, a next-gen screening method to address this📣. #PrecisionGenomics

In this Orli Bahcall commentary, I reflect on an older paper from the Campbell group Wellcome Sanger Institute showing how normal skin is full cancer mutations yet stays healthy to highlight the opportunity to revisit this question using new spatial omics tech: nature.com/articles/s4157…