Super excited to release our latest work in bioRxiv on #PolG, #mitochondria and skeletal #muscle. This study led by @Simon23206236 and @Eking_Sci describes a novel conditional PolG model that allows for tissue specific alterations in #mtDNA integrity 🧵 /1

Senescent glia link mitochondrial dysfunction and lipid accumulation nature nature.com/articles/s4158…

Delighted to share the last study of the lab led by the fantastic postdoc Luis Carlos Tábara Rodríguez out in Cell !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. MRC MBU Cambridge University authors.elsevier.com/sd/article/S00…

Thank you #AGE2024 for the Women In AGE Scientific Achievement Award. Now I'm getting ready for #worm24 in Madison, WI again! #celegans

1. Cuervo lab is excited to announce our latest publication! 🤩 PNASNews pnas.org/doi/10.1073/pn…

We're thrilled to announce our next research webinar on Mitochondrial Ageing by Dr. Manish Chamoli Manish Chamoli, a research scientist at Buck Institute! Date: 9th July Time: 10 a.m. IST Do register and spread the word! events.teams.microsoft.com/event/c96da6a0…

Impressive study showing that inhibiting interleukin-11, a pro-inflammatory cytokine, extends lifespan in mice by 25%. Both genetic deletion and an anti-IL-11 drug worked, and it's exciting that anti-IL-11 therapies are already in human clinical trials. nature.com/articles/s4158…

Interested in ketone bodies and BHB? I had a lot of fun writing this one pager intro/catch-all with Brianna Stubbs for Cell Press, check it out here: authors.elsevier.com/a/1jRnS3jDgWq3…. Proud to call this my first, first-author pub!

Join us on Mon, Aug 12 at Buck (or on Zoom) for the Inaugural Judith Campisi Symposium! Cellular Senescence: The Road to Immortality. Featured Speakers include Norman Sharpless, Thomas Rando, @jhelisseeff.bsky.social, and Miranda Orr OrrLab Register today: buckinstitute.org/events/cellula…

Register now for "Molecular and Cellular Aging" Sept 10-11, La Jolla, CA. Immediately following NIH SenNet Mtg. Reg closes Aug 12. Submit Abstract for Short Talk/Poster. Registration limited. Please re-Tweet. rio.pitt.edu/2024-molecular…

Grateful for the support from the Larry L Hillblom Foundation, which has been crucial for my research and career. Special thanks to Peter J. Donnici, Prof. Ana Maria Cuervo, and the Scientific Advisory Board for their invaluable support.

𝐆𝐞𝐧𝐞 𝐭𝐡𝐞𝐫𝐚𝐩𝐲 is a treatment that delivers fragments of DNA to cells to replace missing or defective DNA or to enhance cell function. Multiple approaches are under development, but currently approved gene therapies involve encapsulating a corrective or therapeutic gene

Preprint spotlight | Can damaged tRNAs drive aging? linkedin.com/posts/manishch…

🗓️ New Deadline: Apply by 15 June 2025 Join our dynamic research community and contribute to pioneering science and innovation. 🔬 Open Positions: • 03 Staff Scientist-III • 08 Staff Scientist-IV 📍 Key Research Areas: Immunology | Infectious Diseases | Precision Medicine |

Silencing mitochondrial gene expression in living cells; science.org/doi/10.1126/sc…

We show a novel role for glycogen in neurons in protection against dementia. Glycogen accumulation is seen in fly, iPSC and human post mortem samples of Alzheimer’s disease. Breaking down glycogen rescues tauopathy by reducing ROS by enhancing PPP. nature.com/articles/s4225…

Cell therapies are breaking new ground, but too few patients can access them. What will it take to scale these treatments so more patients can benefit? Read the piece we wrote examining the bottlenecks and emerging solutions. longgamevc.substack.com/cp/171293688

Tariffs, $150B+ in new pharma manufacturing, FDA’s PreCheck program, and NIH limits on foreign collaborations, all signs the U.S. wants to “build it here, keep it here.” Here’s a short piece on what that could mean for startups and biotech investors: manishchamoli.substack.com/p/build-it-her…