🧬A Doudna lab paper from nature is here 👇👇 How does a bacterial immune system detect viruses by monitoring its own defense signaling, rather than sensing the virus directly? UC Berkeley "A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling" •

We are pleased to share our new preprint: “De novo design of RNA and nucleoprotein complexes”. This work extends the principles of de novo protein design to RNA and DNA, enabling the generative design of complex multi-polymer structures! (1/6) doi.org/10.1101/2025.1…

Combining expansion microscopy with super-resolution radial fluctuations captures the morphology of single proteins go.nature.com/3Y1FD8M rdcu.be/eI29D

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density. elifesciences.org/articles/10033…

This year’s medicine laureate Shimon Sakaguchi discovered a new class of T cells. Sakaguchi was swimming against the tide in 1995, when he made a key discovery. At the time, many researchers were convinced that immune tolerance only developed due to potentially harmful immune

Excited to share Caliby 🐈, our new model for structure-conditioned sequence design! Caliby is a Potts model-based sequence design method that can condition on structural ensembles. We use this to average out non-structural signal (e.g. evolutionary bias) learned by models 🧵1/N

Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing advanced.onlinelibrary.wiley.com/doi/10.1002/gg…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Physics to John Clarke, Michel H. Devoret and John M. Martinis “for the discovery of macroscopic quantum mechanical tunnelling and energy quantisation in an electric circuit.”

The benefits of disorder The presence of an intrinsically disordered region in a transcription factor enhances both target binding and search efficiency. elifesciences.org/reviewed-prepr…

(Preprint of my PhD project) Unveiling the unique interaction mechanism of herpes simplex virus 2 glycoprotein C with C3b biorxiv.org/content/10.110…

A structure for myoglobin was uploaded to the PDB when it launched in 1971. A low-resolution structure of the flagellar motor came in 2006. By 2020, we got the entire flagellar motor, with its hundreds of proteins, at high resolution. So much progress in only 50 years. (Not

A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors go.nature.com/3Jc62gv

i spent a small fraction of my unemployment working on cartoonifying proteins in nicer ways

NYSBC will be offering our biennial SPA cryoEM short course March 16-20, 2026: nccat.nysbc.org/activities/cou… The regular application deadline is December 15, 2025 by 5pm. Accepted applicants will be informed in early January 2026.

End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC biorxiv.org/content/10.110… #biorxiv_biophys

Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (Cell Biomaterials, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : cell.com/cell-biomateri…

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density. elifesciences.org/articles/10033…

Intrinsically disordered proteins are dysregulated in disease, but have been considered 'undruggable'. This Review in the October issue discusses experimental and computational approaches to conquer this barrier in drug discovery rdcu.be/eMbXh nature.com/articles/s4157…

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! uu.nl/en/news/33-mil…

How Do Proteins Fold? Today, AI can predict a protein’s final shape with incredible accuracy, thanks to tools like AlphaFold, but, we still can’t predict how a protein gets there. We’ve known for decades that the information to fold is inside the primary structure of amino acid