It was a great pleasure to welcome Vera Pancaldi verapancaldi.bsky.social and Matthieu Foll 🦋 @matthieufoll.bsky.social for CoBiCa24 (cobica2024.sciencesconf.org/program), a workshop related to computational biology and cancer in Grenoble. We were almost 100 participants in this great event, also welcoming great short oral presentations and posters!

Thank you #ENETS24 for this award! The Clevers Lab Hubrecht Institute Rare Cancers Genomics UMC Utrecht International The Netherlands Cancer Institute Maastricht UMC+ EMBL Barcelona Nicolas Alcala Matthieu Foll 🦋 @matthieufoll.bsky.social @FCLynnette @DerksJules 👀 🧵about our work x.com/TalyaDayton/st… & preview cell.com/cancer-cell/ab… by Stefanie Gerstberger, MD PhD Karuna Ganesh

Thrilled to announce that Institut national du cancer has awarded a 5 yr label to the COALA (Cure Oncogene Addicted Lung Adenocarcinoma) network that gathers 15 research teams in France. Looking forward to starting the program and improving patients outcome. CHU de Toulouse - compte inactif CRCT-Oncopole

Congrats to émilie Mathian, the Rare Cancers Genomics team and a stellar team of expert pathologists who teamed up to advance the diagnosis of lung #neuroendocrine #tumors with emerging markers and #deeplearning 👏 sciencedirect.com/science/articl… ESMO Open

💬 “Making #data publicly available should no longer be a by-product but a recognised part of the #research process” 💡Our Executive Director Christophe Dessimoz was at the SCNAT symposium “Open Research Data (ORD) – are we on track?” last 31 May. more on👉 scnat.ch/en/uuid/i/6796…

Are computational biologists the drivers of research? 7 years ago I co-wrote an editorial about how computational biologists are no longer just supportive, but are now running the show. Today I would write how every biologist should also be computational. genomebiology.biomedcentral.com/articles/10.11…

Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank

Tumor heterogeneity is a major obstacle to effective cancer treatment. It is caused by multiple factors, including irreversible mutations and reversible phenotypic changes. But how can we model the interplay between both processes and what's their effect on cancer treatment? 1/

Assessment of methods to deconvolve cellular composition from bulk gene expression. #DREAM, #Immunotherapy, #deconvolution nature.com/articles/s4146…

New research from katherlab on #computational #pathology: We benchmark pathology foundation models 👇 Several of these are publicly available under permissive licenses. arxiv.org/abs/2408.15823 Some takeaways: 1. The vision-language model CONCH (Faisal Mahmood) outperforms

Can tumours be described as complex ecological systems? What is the mathematical description of their dynamics and treatments? Check our iScience journal paper with Guim Aguadé-Gorgorió and Sandy Anderson in cell.com/iscience/fullt…

Very happy to share our opinion on the need for a naming convention for #peritumoral tissues (#PTT)! Great work by Dzenis Koca with Dr Behnoush Abedi-Ardekani and Dr Joël Le Maoult! nature.com/articles/s4141…

Happy to share our first preprint using Chilean cancer data! 🎉 We developed a Nextflow pipeline for BRCA profiling, aiming to implement NGS testing in Chile's public health system. Universidad de O'Higgins Universidad de O'Higgins #brca #nextflow #ngs medrxiv.org/content/10.110…

Very happy to share our latest work on pulmonary carcinoids published in Journal of Clinical Oncology: TERT Expression and Clinical Outcome in Pulmonary Carcinoids ascopubs.org/doi/10.1200/JC… Thanks to all involved! SFB1399 Department of Translational Genomics Uniklinik Köln Charlie Rudin Natasha Rekhtman MD PhD Matthieu Foll 🦋 @matthieufoll.bsky.social Alex Di Genova

We are thrilled to welcome Yuliya Lim as a PhD student in the team, under the supervision of Nicolas Alcala, L. Fernandez-Cuesta, and Matthieu Foll 🦋 @matthieufoll.bsky.social! Yuliya recieved a competitive PhD fellowship from La Ligue contre le cancer and will work on deciphering the mysteries of cancer ecosystem complexity.

The Curated Cancer Cell Atlas: comprehensive characterisation of tumours at single-cell resolution biorxiv.org/cgi/content/sh… #biorxiv_cancer

Semi-supervised Omics Factor Analysis (SOFA) disentangles known sources of variation from latent factors in multi-omics data biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

'Emerging strategies to investigate the biology of early cancer' nature.com/articles/s4156…

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in nature nature.com/articles/s4158…