Irvine and colleagues suggest that targeting IL-12 and IL-15 to CD45 is an effective antitumor treatment and limits adverse effects associated with cytokine therapies. Read it here: rdcu.be/dQQkz nature.com/articles/s4159…

Tumor-immune systems biology. All my favorite words in one center at MSK For those that thrive in complexity. #NCICSBC

Yu-Lan Kao: Organ specific immune responses to metastatic tumors. Liver mets more immune suppressed, lung mets more immune reactive. Macrophages may be to blame. #NCICSBC

Delighted to share our paper on adipose gd T cells making IL-17 every night for homeostasis, coordinating lipid metabolism after eating nature Huge effort by Aaron Douglas & Brenneth Stevens and the team and collaborators to work this out. Aaron's Tweetorial 👇 nature.com/articles/s4158…

✍️Submissions are invited for the special issue on computational models in cancer immunotherapy of Cells MDPI journal mdpi.com/journal/cells/… Deadline: March 31 2025

This underscores the complexity of the innate immune system, which remains a black box. Unlike the adaptive immune system, where some mechanisms are well understood, we have little insight into how the innate system operates, integrates signals, or interprets them. #immunology

Are you interested in joining the only mathematical oncology department IMO in a cancer center Moffitt Cancer Center in the world? We have an open rank tenure track position (assistant/associate/full) available now and would love to hear from you! Apply here: …cancer-center-careers.hctsportals.com/jobs/1859278-o…

Day one of an exciting workshop "Cancer Dormancy and Therapy Resistance"

Sara Soliman: highlights the difference between Resistance and Persistence

Save the date #MathOnco25! October 29th-31st in Tampa, Florida. Directly before the 13th IMO Workshop (November 3rd-7th) - stay the weekend and brainstorm the beaches! More information to follow but Centre for Evolutionary Therapy will be a key theme IMO Moffitt Cancer Center

Wishing a very Happy Retirement to Geri Rodriguez. The heart and laughter of our crew for over 15 years!!! Moffitt Cancer Center

#SpatialOmics The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs 15 M cells 100 donors 10 organs Liver Pancreas Bone marrow Lymph node PBMC Prostate Stomach ILeum Colon Appendix CosMX 1k 6k WTA Xenium GeoMx RNAscope

Fascinating science chats in Today's lab meeting discussing Bob's recent paper written with Jill Gallaher Hemachander Subramanian and others. "On the Origin of Information Dynamics in Early Life" mdpi.com/2075-1729/15/2…

Editorial Kimberly Luddy: extending the functional lifespan of NK cells: towards durable cytotoxicity in NK-cell based immunotherapy bmjoncology.bmj.com/content/4/1/e0… on bmjoncology.bmj.com/content/4/1/e0…

This announcement from the NIH is fantastic “NIH will no longer seek proposals exclusively for animal models” All new proposals should include modern alternatives: e.g. computational modeling and organoid style technologies w human components IMO drugdiscoverytrends.com/nih-announces-…

The role of glycans in human immunity—a sweet code: a comprehensive review about the role of glycans in the immune response. tinyurl.com/yrrdz5sp #glycotime

💉 Checkpoint inhibitors help many melanoma patients, but not all respond. A study finds that TGF-β activity isn’t a reliable predictor, highlighting the complexity of immune resistance. 🧬🛡️ Read the full article here 🔗 bit.ly/45zZcc5