🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Today is Sci-Hub anniversary the project is 10 years old! I'm going to publish 2,337,229 new articles to celebrate the date. They will be available on the website in a few hours (how about the lawsuit in India you may ask: our lawyers say that restriction is expired already)

Researchers learn a lot about human diseases from studying biological pathways! Identifying which genes, proteins and other molecules are involved in a pathway can provide clues about what goes wrong when a disease strikes. Learn more in our fact sheet! bit.ly/3nkzJyI

Out of the 6 billion letters in our genomes, each of us has around 4 to 5 million genomic variants. These variants could either be incredibly unique to us or may show up in other people’s genomes. Why do these variants matter?

Diseases that come from several genomic variants and environmental factors are called complex, or polygenic diseases. One example is coronary artery disease. People with this disease tend to have 60+ of the same variants that are spread across the genome.

Genomic variants reflect different DNA spellings among people. It is important for researchers to be able to identify genomic variants and then readily determine IF and HOW they influence human health and disease.

Our covid times :-( by Matt Davies

medrxiv.org/content/10.110…

When you tell an 'omics lab to dress up for Halloween.. Ryan Corces

The entire GWAS community should be thankful to the authors for curating GWAS results, fine-mapping causal variants, prioritizing causal genes using an impressive workflow and finally handing in the results to us in a silver platter that is opentargets.org. 👏👏

Compared to the original book cover, I kind of prefer AI's interpretation (app.wombo.art) of my PhD dissertation..."The Genetics of Heart Rate Variability"

ShaPRS: Leveraging shared genetic effects across traits or ancestries improves accuracy of polygenic scores medrxiv.org/content/10.110… github.com/mkelcb/shaprs

Most genomic studies have been done with participants who have European ancestry. Because of this lack of diversity, there might not be enough data about genomic variants from other populations to calculate polygenic risk scores for those groups. go.usa.gov/xeuGX

I'm excited to listen to all my bookmarked The Festival of Genomics & Biodata talks tomorrow. I'm sure the early start, due to time differences, will be totally worth it! #Genomics #biodata

I simply can't resist adding this extra hierarchy level whenever I show this pyramid

I am writing a book to help wet biologists to learn computation. Below are some of the chapters I have in mind. What else do you want to know? what problems and frustrations did you have when you started? I will keep them in mind. #rstats #computation #Bioinformatics RT please

Genotype Imputation From Array Data Can Approximate Sequencing in Some Cases, Study Finds. Imputation quality varies by reference panel, genotype array, and other factors, the researchers found, and the approach is currently not suitable for clinical use. ow.ly/Y6hx103UtsA

In case you missed it, Jonny Coates (jacoates.bsky.social) was quoted in this piece shining a light on *some of the issues postdocs are facing nature.com/articles/d4158… *there are so many more issues ofc.

We've seen many examples of rare coding variants pinpointing causal gene at GWAS loci. Here is an interesting case where a somatic coding variant pinpoints the causal gene at a GWAS locus. 🧵

Great to see our work from the CARDIoGRAMplusC4D Consortium on the genetics of coronary artery disease finally out in Nature Genetics nature.com/articles/s4158… A short 🧵 to highlight some key findings..... 1/8

🕯️