Happy holidays! Introducing RTutor.ai, an AI-powered app that lets you chat with your data in English! RTutor uses Davinci (#ChatGPT’s sibling) to turn requests into R code, which is executed & results are shown instantly, available as a HTML report in seconds. 1/8

I had this hanging on my office door for a couple of years. A nice illustration of how limits do/don't work.

Some thoughts on core facilities. 1. These are enormous all-boat lifters if supported well. 2. They should be run by experts who are commensurately valued and supported. This is a career path. Include names on papers if they’ve contributed insight, even if fee-for-service. /1

The speed of light visualized on a cosmic scale. Credit: Dr James O'Donoghue

BioGPT, a domain-specific generative model pre-trained on large-scale biomedical literature, has achieved human parity, outperformed other general and scientific LLMs, and could empower biologists in various scenarios of scientific discovery. Learn more: msft.it/6014eAnLq

01. Today we report the computational design of highly efficient enzymes. Lab testing confirms that these novel luciferases can recognize specific synthetic substrates and efficiently catalyze the emission of light. nature.com/articles/s4158…

Preprint from our group on the structural basis of SARS-COV-2 spike trafficking and incorporation into progeny virions. Wonderful collaboration with Enya Qing Pierce Lab Lokesh Gakhar Nick Schnicker Debajit Dey #COVID19 #spike #Coronavirus #crystallography biorxiv.org/content/10.110…

That's the reason I love #electronmicroscopy You can see cool stuff like this :D Any ideas what's going on here?

In my SciComm class, I had students individually rank the efficacy 14 popular Science Communications methods based on their own rubrics. Here are the results, as a calculated average! Use the information as you will, Academic Chatter™. Congratulations TED Talks

IT'S FINALLY HERE! A story years in the making about how cells handle misfolded proteins in the nucleus and cytoplasm 1/12 #proteostasis #proteinfolding nature.com/articles/s4155…

⚛️Protein structures are key to elucidating molecular details of cellular processes. #AlphaFold2 & others unveiled millions of tertiary structures, but these proteins' quaternary structures remain mostly a mystery. Here's how to bridge the gap. Thread👇 biorxiv.org/content/10.110…

Scientists in the Baker Lab have designed new proteins that change shape upon binding a target molecule. This research opens the door to new applications in drug delivery, environmental sensing & more. Florian Praetorius, Phil Leung bakerlab.org/2023/08/17/swi…

It turns out that sparkling water and raisins are *fascinating*. My daughter and I happened upon this effect playing together in the kitchen a long time ago, and I couldn't help but explore the system more deeply... 1/n arxiv.org/abs/2308.12927

Surprising shapes and unexpected connections have been discovered in the dark corners of the protein universe thanks to Google DeepMind’s revolutionary AlphaFold neural network nature.com/articles/d4158…

A monumental work by many in my lab and Protein & Crystallography Facility , and another wonderful collaboration with Pietro Pichierri 🇮🇹🇪🇺 @[email protected] and his team! A double-ring of human RAD52 remodels replication forks restricting fork reversal biorxiv.org/content/10.110… Morteza Nick Schnicker Lokesh Gakhar

1/n: We are excited to share that our paper on Chroma, a general purpose diffusion model for proteins, is out today in nature! nature.com/articles/s4158… A couple of my favorite highlights in the 🧵below 👇

How to design binders to any small molecule ligands, flexible or polar? How to turn binders turned to sensors without complicated engineering? We solved these 2 problems with a single method, binder and sensor design through shape complementary pseudocycles.

Time to ditch BioRender? I had no idea they were claiming copyright to the figures we make with it, even after we pay for use of the service.

🧬📢We're hiring a postdoc! The lab is in an exciting phase that combines multidisciplinary scientific approaches with an incredible team of fun supportive people! Check out more at our lab page (see profile) and consider applying here: tinyurl.com/4zmewj9t Please RT🙏

We have trained ESM3 and we're excited to introduce EvolutionaryScale. ESM3 is a generative language model for programming biology. In experiments, we found ESM3 can simulate 500M years of evolution to generate new fluorescent proteins. Read more: evolutionaryscale.ai/blog/esm3-rele…