Compared to low-volume physical activity, high-volume physical activity is associated with a lower risk of all-cause mortality but similar risk for clinical CAD events. ahajournals.org/doi/epub/10.11…

Our review paper about time-restricted eating as a tool for hormesis in CV risk reduction has been published in Conditioning Medicine! We share a comprehensive review of preclinical & clinical data on TRE. I always love writing with Pam R. Taub, MD❤️💃🏻 💃 conditionmed.org/Data/View/16927

Congrats to Elizabeth Sage Epstein, MD for leading this article where we discuss hormesis which is the concept of exposing the body to small doses of intermittent stress to activate biochemical and molecular pathways that evolved to sustain living things through hardship. Hormesis is the

Really enjoyed talking #prevention at UCSD’s Red Dress Gala last night to raise money for women’s CV health research ♥️🫀Your heart health is in your hands!

Can’t wait for RISE at European Society of Cardiology ESC Congress Madrid 2025! Women As One

What can't metformin do? Metformin decreased the risk of renal function deterioration, according to a retrospective observational multicenter cohort study included 316 693 patients with type 2 diabetes. The metformin group was revealed to have better renal outcomes than the

Daily supplementation with 2,000 IU of vitamin D slows the rate of telomere shortening, preserving telomere length equivalent to delaying ~3 years of biological aging over four years. Telomeres are protective DNA sequences that cap the ends of chromosomes and are critical for

What an amazing editorial by Sniderman et al - sadly firewalled - "Incorporating apoB and Lp(a) into routine clinical care will improve assessment of CV risk due to the apoB lipoproteins. Adopting apoB as the primary measure of the effectiveness of therapy will radically

In patients with nonobstructive HCM, there was a reduction in myocardial T1 time with eplerenone, consistent with a reduction in diffuse myocardial fibrosis. Larger and longer trials are needed jacc.org/doi/10.1016/j.… #JACCHF #cvHCM

It's never too late!! Lifestyle Interventions to Improve Cognition in Later Life: When Is Enough Enough? Used diet, physical activity, cognitive training, and vascular risk management. Many of the measures were directed at metabolic and cerebrovascular disease health

SOGALDI-PEF: In pts w/ HFmrEF/#HFpEF, the combination of dapagliflozin plus spironolactone led to a greater reduction in NT-proBNP levels than dapagliflozin alone, indicating improved cardiac stress. Learn more: 🔗 bit.ly/46AURr8 #JACC JACC Journals

Our Nature Medicine paper on glucose spikes (CGM sensor) and their relationship with physical activity, gut microbiome, genomics, food intake, and sleep via multimodal A.I. Helps identify people with prediabetes who have high risk of progression (cf HbA1c) nature.com/articles/s4159…

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain science.org/doi/10.1126/sc…

When #HeartFailure meets #CVPrev & it becomes the center of everything we do, we can start saving hearts. Our joint ASPC Journal of Cardiac Failure statement: The Continuum of Prevention & Heart Failure in Cardiovascular Medicine cochaired by myself & Anu Lala-Trindade shorturl.at/ucRP6

New in #JACC HF: -Among those with LV dysfunction after #MI, high aldosterone is associated with higher #HF event rates -Eplerenone decreases #HF events in these patients shorturl.at/KHhMr

So much fun talking comprehensive cardiovascular risk assessment to the Scripps CV fellows today. I did bribe them with coffee & warm bran muffins, but imho there’s nothing better than starting the day with #PrecisionPrevention. Thank you for inviting me Rola Khedraki, MD, FACC 🫀♥️