Evolutionary adaptation of the chromodomain of the HP1-protein Rhino allows the integration of chromatin and DNA sequence signals biorxiv.org/cgi/content/sh… #bioRxiv

The @juliusbrennecke group shares an update on last year's Kipferl discovery by Lisa Baumgartner.

I'm actively looking for a post-doc position in reproductive/dev bio and have a particular interest in understudied/endangered species linkedin.com/pulse/imployab… please share! #postdoc #postdocjobs

We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in nature nature.com/articles/s4158…. Thread 👇(1/N)

Exciting news! Our latest research on "Cell type directed design of synthetic enhancers" has been published in nature. We've harnessed deep learning to design enhancers with cell-type specificity. Find our paper here: nature.com/articles/s4158…. Highlights below: [1/n]

Yay! Super happy to see my paper out in EMBO Reports. Thanks to all the people involved in the work, the reviewers and the editor. For a summary, check out the interview below 👇 or this threat 🧵: x.com/llorenzoorts/s…

This month we had the last happy hour in our current building. The event marked the end of an era, complete with piñata smashing, poster graffiti and intense Jenga battles🎊Exciting times ahead as we gear up to move to a new home soon! Keep watching this space for more🏢✨

Peters Lab: Excited to share our latest preprint lead by Greg Fanourgakis (Grigo Fanou). Key findings are that DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos. biorxiv.org/content/10.110…

Over 4 years in the making, I am excited to share our pre-print on the “In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography”. We used cryo-ET to resolve the copia capsid structure to subnanometer resolution inside cells. A 🧵

We're looking for a Managing Director of our scientific core facilities - details: viennabiocenter.org/fileadmin/user…. Come work with us - 6 basic research institutes & 40 biotech companies, >2000 scientists from 85 nations - at the vibrant Vienna BioCenter in Vienna, Austria. Please RT.

I’m beyond excited to present my postdoc work with Plaschka Lab and @JuliusBrennecke at IMP IMBA imbavienna.bsky.social . We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. A thread: 1/x

Congratulations to Julius Brennecke for securing one of this year’s European Research Council (ERC) Advanced Grants! Julius will study the arms race between transposons and host genomes. #ERCAdG More here: oeaw.ac.at/imba/research-…

Excited to share our latest preprint. Lead by Sevi (Sevi Durdu) we asked how transcription factors (TFs) with short and abundant motifs drive specific cell fates. Our test cases: Two bHLH factors that bind to seemingly similar E-boxes. 1/7 biorxiv.org/content/10.110…

New Study Alert! A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin biorxiv.org/cgi/content/sh… #biorxiv_molbio

It is challenging to study the ability of transcription factors to engage their motifs in the cell. We tried to address this in our new study together with Marco (Marco Pregnolato), Schübeler Lab, and FMI science: cell.com/molecular-cell…

To pioneer or not to pioneer...! Or is it a bit more complicated after all? Check out the latest from the Schübeler Lab, a huge effort by Marco Pregnolato and Ralph Grand 🎉 (featuring the first small snippets of my PD work 😊)

Cells turn genes on and off with the help of transcription factors, but binding to DNA is complex. Marco Pregnolato, Ralph Grand and others in the Schübeler Lab found that these factors act more variably than expected, sometimes displacing nucleosomes only in certain regions 🧬