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Why sleep is important! biorxiv.org/content/10.110…

Vista impresionante de la médula espinal humana y las pulsaciones del líquido cefalorraquídeo.

An improved understanding of the anatomy of brainwashing could lead to the development of therapeutic approaches that might transform the treatment of a variety of neurological diseases. Learn more in a new #SciencePerspective: scim.ag/8d9

Classical pathway of CSF flow, not updated to the latest knowledge

Boom! Cerebrospinal fluid (CSF) flow extends to peripheral nerves. Alexander Ligocki, Ed Scott and colleagues FLORIDA UF Health blow our minds. New paper Science Advances. What will we call it now? Cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Just when

CSF circulation #neurotip #neuroanatomy

It is safe and feasible to remove blood from CSF system in an accelerated fashion via active CSF exchange. Active removal of blood reduced adverse events in subaracnoideo hemorrhage journals.lww.com/neurosurgery/a….

The glymphatic system is an emerging therapeutic target for proteinopathies. Sharkey et al. show that individuals with ALS have reduced glymphatic function compared to age-matched controls and people with primary lateral sclerosis. tinyurl.com/ymm52vm5

Next week will be at CTAD presenting our implantable device for intrathecal #pseudodelivery of immunotherapies. Particularly we will show the preclinical testing (in pigs) of a prototype for humans. Drop us a message if you are interested on this new route of delivery

Gross Anatomy and Surface of Brain Craniometric Points and Surface Anatomy⚡️ ⬇️ youtube.com/live/e-rwPdQZM…

Using intrathecal gadolinium contrast-enhanced MRI, authors show that contrast-enhanced CSF moves through the perivascular space into the parenchyma, supporting the existence of a #glymphatic pathway in humans for the first time! NedergaardLab pnas.org/doi/full/10.10…

Glass spine model to show the effect of #baricity in #intrathecal drugs youtu.be/rFAyTRvMBOE?fe…

Correlation analysis between CSF and plasma oligomer concentrations indicates an impaired clearance of Aβ oligomers that is dependent on the ApoE status nature.com/articles/s4385…

#Intracerebroventricular anaerobic dopamine in #Parkinson’s disease with l-dopa-related complications: a phase 1/2 randomized-controlled trial nature.com/articles/s4159…

MRI free water mediates the association between diffusion tensor image analysis along the #perivascular space and executive function in four independent middle to aged cohorts #glymphatic #dementia neurosciencenews.com/glymphatic-sys…

Out today in Cell ! We show that oscillations in norepinephrine and cerebral blood volume are the missing pieces that link NREM sleep to clearance of waste from the brain 🧠💤 cell.com/cell/fulltext/…

the use of a cerebrospinal fluid catheter is a feasible approach for spinal cord injury risk reduction in selected high-risk patients undergoing aortic aneurism repair journals.sagepub.com/doi/10.1177/15…

Soluble Abeta oligomers are the most interesting target in #Alzheimer’s, and #intrathecal #pseudodelivery of mAbs is the most promising technique to achieve their clearance from the #CNS mdpi.com/2079-9721/13/1…

#Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and #Alzheimer's disease neurotherapeuticsjournal.org/article/S1878-…

Time to go with the flow! Knowing vascular anatomy is the first step to reading any angiogram These are the key vessels you need to know! Then I always remember to check for pathology using the mnemonic ANGIO to remind me what to look for: A = aneurysms, arteriovenous