Great to see our work published: Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice life-science-alliance.org/content/5/8/e2…

A web interface💻 with access to data on #myelin differences in humans and mice 🐁: This has been developed by researchers at our institute led by @TingSun_MPINAT, Olaf Jahn & @werner_hauke, supported by the GWDG. mpinat.mpg.de/4126889/rn_2202

In this paper, we showed that the neurovascular coupling (NVC) response, or as we call it axo-vascular (AVC) response, in a white matter tract, such as the optic nerve, is quite different from the NVC of grey matter.

Congratulations 🎉

Oligodendrocytes and neurons contribute both to amyloid-β deposition in models of Alzheimer's disease. Great work by Andrew Sasmita, Constanze Depp et al. biorxiv.org/content/10.110…

In a mouse model of #Alzheimer’s disease, amyloidosis itself triggers age-related #oligodendrocyte and #myelin damage mediated by CD8+ T cells that promote the accumulation of interferon-activated myelin-damaging #microglia nature.com/articles/s4159…

Oligodendrocytes produce amyloid-β in AD mice and reveal a threshold for plaque deposition. Great study by Andrew Sasmita, Constanze Depp et al. nature.com/articles/s4159…

Great work by @sophiesiems @SGargareta Vinicius Gastaldi Hauke Werner etc. investigating CNS myelin proteomic heterogeneity across different ages, sex, and major regions in vivo 🐚👏 onlinelibrary.wiley.com/doi/10.1002/gl…

Great to see the Alzforum coverage of our recent Nature Neuroscience paper alongside two separate studies that showcase the oligodendroglial contribution to Aβ burden in vivo 🧠

Microglial lysosomes may be a crucial incubator for amyloidosis. There, ApoE and Aβ co-aggregate, forming seeds of Aβ plaques. @DZNE_en ow.ly/wGET50TWHtC

Happy to share this recent review with Mika Simons - White matter aging and its impact on brain function: Neuron cell.com/neuron/fulltex…