Really excited to share work from our team at Ginkgo Bioworks, led by Alyssa Morrow, on ML guided 3’ UTR design. biorxiv.org/content/10.110… It's a great story of dataset generation, model training, generative design, in-vivo validation, and model release. More details in thread!

David Baker, Demis Hassabis and John Jumper received the 2024 #NobelPrize in Chemistry “for computational protein design.” In June, Yasemin Saplakoglu covered Baker, Hassabis and Jumper's work in an extended story for Quanta. Revisit that coverage here, or in the thread below.

Inside the brain of a protein language model 🔍 A thread on reverse engineering neural networks: Some methods, challenges, and rabbit holes on the 20 amino acids—the building blocks of life.

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy Wohlwend, Saro and an amazing team at MIT and Genesis Therapeutics. A thread!

Biotech VCs often complain that scientist-founders aren't good at product development but we should cut them some slack knowing they were trained in a culture where nature magazine thought people would pay $8.99 to rent an article on readcube

Congrats on the release of ESM-C! We rewrite ESM-C with flash attention and now u can save 70% of time and 60% of memory with `pip install faesm`. Check it out on GitHub: github.com/pengzhangzhi/f…

It's launch day for mDD-0, the latest model from Ginkgo AI! Read the white paper about generative AI for full-length mRNA sequences including custom therapeutic payloads. We're excited to see what you'll build! hubs.la/Q036BJ-W0

Working with an interdisciplinary team, we have developed a website to communicate how the White House's proposed cuts to health research would cause losses of $16B and 68,500 jobs. Find out how your community may be impacted. Explore more at SCIMaP: scienceimpacts.org

In 1956, 26-year-old Edsger Dijkstra invented a classic path-finding algorithm while out with his fiancée at a café in Amsterdam. It all happened in his head: “Without pencil and paper you are almost forced to avoid all avoidable complexities,” he said. quantamagazine.org/computer-scien…

An update on Fractal Tech Bootcamp, and a request for help 🙏🏼 I started an AI engineering accelerator (a “bootcamp”) about 1 year ago, because my friends and I could not find enough good AI talent to hire, and I’m obsessed with educational reform. The bootcamp was an

We are at risk of losing our drug discovery startup ecosystem in US. We really need to stay on top of this if we want the US to own innovation in medicine-- should be top priority at NIH/FDA.

So, apparently, among the blanket grant cancellations at Harvard is the grant supporting HMMER (github.com/EddyRivasLab/h…). Immensely stupid move! Not in recent memory, perhaps ever, has there been a US administration more anti-American and self-sabotaging to it's core.

We are now accepting applications for SFARI data analysis awards, which will provide support for scientists interested in working with and publishing from previously collected data relevant to the basic science of autism: sfari.org/2025/07/01/app… #science #autismresearch

Mapping the off-target effects of every FDA-approved drug in existence (EvE Bio) 6.2k words, 29 minutes reading time owlposting.com/p/mapping-the-… this is a very long essay over EvE Bio, a data collection effort that you should know about (it's associated w/ Convergent Research!)

Awesome new offering from Ginkgo Datapoints -- we will price match any ADME service quote you get (including from Chinese or other international vendors). We plan to have the best per-compound pricing out of the gate anyway --our automation at Ginkgo allows best in class

Absolutely phenomenal exchange from Rep. Scott Perry at a recent US House hearing about AI – demonstrates way more understanding of the issue than is typical: Rep Perry: “I do want to make everybody aware of some things that I am aware of. I’m going to refer directly to an AI

Ginkgo has launched an E.coli-based Cell Free Protein Synthesis reagent! reagents.ginkgo.bio/products/cell-…

Never in baseball's 150-year history has a player finished a game with at least six hits, six runs and eight RBIs until Nick Kurtz tonight. His 19 total bases tie Shawn Green's single-game record -- and Kurtz had one more RBI. There's a genuine argument it is the best game ever.

Ginkgo Automation is proud to support the Environmental Molecular Sciences Laboratory (EMSL) at Pacific Northwest National Laboratory (PNNL) in accelerating microbial research to power the bioeconomy. Through this collaboration, Ginkgo will deploy flexible, modular automation

Want to join our efforts Microsoft Research AI for Science to push the frontier of AI for materials? We are the team behind MatterGen & MatterSim and we have 2 job openings! Each can be in Amsterdam, NL, Berlin, DE, or Cambridge, UK. It is a rare opportunity to join a highly talented,