Emma Coomans just presented our large-scale tau PET study (>11,000 participants from 41 cohorts) providing robust prevalence estimates of tau PET-positivity as a function of age, amyloid, sex and APOE. #AAIC24 Many thanks to all our collaborators worldwide (way too many to tag)!

A friendly reminder that our ISTAART Design and Data Analytics PIA All Member Meeting is happening tomorrow (Tuesday 09/10) at 2 p.m. CT! Join us if you can 😎 Lars Lau Raket Ana Capuano Mike Malek-Ahmadi Natalia Goncalves Jet M.J. Vonk, PhD PhD Nicolás

Interested in the density of regional tau pathology that is needed for tau-PET to reliably detect it? Here we performed a very detailed comparison of the regional FTP PET retention antemortem to the regional amount of AT8 positive tau aggregates postmortem. Check out fig 3! 🤩

Excited to share the REAL AD design paper, now out in Alzheimer's & Dementia Journals The study has been live for 5 months, and we are elated and grateful that 5000 participants have already enrolled! Stay turned for first results! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Always my favourite post at the beginning of the year: Registration for our course “Biomarkers for neurodegenerative diseases” is now open! This year’s edition takes place at UCL Queen Square Institute of Neurology in central London on May 12-16. biomarker-course.org

New Alzheimer blood biomarker! Plasma eMTBR-tau243 correlates strongly with tau tangle pathology, brain atrophy and cognitive decline. I believe it will complement p-tau217 in clinical practice and in many trials. rdcu.be/efPge

biology is nothing but trouble

There is now something new under the sun: you can literally experience a completely new perceptual color that no one has ever seen before

Strong title:

Our most important paper, out now! A massive international collaboration, led by Alexis Moscoso Rial, featuring over 6500 visually assessed tau PET scans covering the #Alzheimers spectrum! Thank you very much to the numerous contributors and collaborators who made this gem possible.

“The arc of history is long, and it bends toward” *flips through history book* Oh. Oh no. Oh no no no

New paper & surprising result. LLMs transmit traits to other models via hidden signals in data. Datasets consisting only of 3-digit numbers can transmit a love for owls, or evil tendencies. 🧵

AI psychosis psychosis is rampant now