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Liu and Bezanilla The University of Chicago describe a voltage-gated sodium channel mutant that removes fast inactivation while the fast inactivation particle, the IFM motif, remains bound, indicating that fast inactivation requires additional conformational changes hubs.la/Q02ZJkSP0

Nav computer modelling as tool to understand fast inactivation: join us for the next worldwide sodium channel seminar given by Ben Corry on December 17th. More info on sodiumchannelseminars.org. Mark your calendar and join the discussions!

first time i've read a science tweet and was like: "this is directly relevant to me cause I'm currently experiencing neuropathic pain and I literally took gabapentin this morning."

Dear ion channel community - come and join us for an exciting talk by @corrylab.bsky.social next Tuesday on sodium channel fast inactivation. Do you still believe in ball-and-chain? Or rather rings obliterating the pore? Something else? Then come and discuss with us at the #WSCS

Excited to share our latest paper in Neurobiology of Pain on the mechanism of action of a compound developed by Dr. Alison Axtman! Check it out! Targeting Nav1.7 and Nav1.8 with a PIKfyve inhibitor to reverse inflam... sciencedirect.com/science/articl…

HOWZAT!!! Distinct embryonic and adult mechanisms of analgesia associated with loss of expression of Nav1.7 - wow!! Sodium channels Nav1.7, Nav1.8 and pain; two distinct mechanisms for N... sciencedirect.com/science/articl…

Happy Holidays! I’m really excited to share this preprint on using Patch-seq and other multi-modal methods to identify the molecular identity of silent nociceptors in the dorsal root gangion in pigs and humans! biorxiv.org/content/10.110… 1/

I can only stress how much fun this fruitful collaboration was and still is. Thank you Shreejoy Tripathy and Derek Howard! Looking forward to hearing your comments #paincommunity #patchseq #ionchannel #pain #itch #microneurography #transcriptomics

A misstep in the multistep process of fast inactivation. Our latest Research News features new work from Yichen Liu and Francisco Bezanilla (hubs.la/Q02_Y3Hj0): hubs.la/Q02_YcKg0

Figure shows mutations at N-linked glycan sites linked to clinical pathologies. Beaudoin, Jackson and colleagues Cambridge Biochemistry show that isoform-specific N-linked glycosylation of Naᵥ channel α-subunits alters β-subunit binding sites. hubs.la/Q02_P5GL0 #ProteinDynamics

In Journal of General Physiology, Köster, Stiehl, Angelika Lampert et al. Uniklinik RWTH AC characterize eight sodium channel subtypes relevant to #nociception & use a computer model to simulate the response of two types of nociceptive nerve fibers. hubs.la/Q033ltkK0 #Biophysics #IonChannels

Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials. New study by Phil Alexander Köster, Thomas Stiehl, Angelika Lampert Angelika Lampert and colleagues Uniklinik RWTH AC: hubs.la/Q033lbQY0 #MolecularPhysiology #Neuroscience #Pain

Computer simulations of action potentials in a CMi. New study by Köster et al. Angelika Lampert provides a better understanding of Nav1.7 and Nav1.9 and has implications for future mechanistic studies and disease modellng. hubs.la/Q033lbMh0 #Neuroscience #Pain #IonChannels

Phentolamine, a non-selective α-adrenoreceptor antagonist, is widely used in clinical settings to reverse local anaesthesia by promoting vasodilation and drug clearance. While generally well tolerated, it has been associated with adverse effects such as tachycardia and,

Miriam Meisler will give our next #WWSC seminar on Feb 25th. Come and discuss Nav1.6 pathophysiology in epilepsy and treatment options: "Down-regulation of SCN8A by ASO or CRISPR-i prevents seizures in a GOF model". Visit sodiumchannelseminar.org for info and link. See you there!

Lovely #VGSC comparison work on nociceptive action potentials. Congratulations to Angelika Lampert lab. #patchclamp #pain #chronicpain #sodium #ionchannels

It will be turbulent in the next worldwide sodium channel seminar: Antonios Pantazis will explain why "Even a single carbon atom matters: deadly and unexpected consequences of a Nav1.5 variant" Tuesday April 29th. Visit sodiumchannelseminars.org for link and infos. #ionchannels

happening today, Tuesday 29th of April!