Fascinating work! Circatidal control of gene expression in the deep-sea hot vent shrimp Rimicaris leurokolos | Proceedings of the Royal Society B: Biological Sciences royalsocietypublishing.org/doi/10.1098/rs…

The Aging Institute is pleased to share the most recent edition of our newsletter, The Chronos Chronicle, Winter 2025. Read more about the exciting research happening at the Aging Institute here: aging.pitt.edu/newsletter-win…

This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:

Interesting work. 12h rhythms of lipid metabolism in the Drosophila fat body, independent of the circadian clock. Circadian clock-independent ultradian rhythms in lipid metabolism in the Drosophila fat body - Journal of Biological Chemistry jbc.org/article/S0021-…

This is a very good review on ~12h biological rhythms. Biological rhythms: Living your life, one half-day at a time | npj Biological Timing and Sleep nature.com/articles/s4432…

Left by the tides | Pitt Med Magazine | University of Pittsburgh. A nice piece on our earlier work on identifying 12h rhythms in ‘free-living” humans. pittmed.pitt.edu/news/12-hour-b…

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A news article on our work. Nuclear Speckle Rejuvenation “Next Frontier” for Treating Neurodegeneration - UPMC & Pitt Health Sciences News Blog inside.upmc.com/nuclear-speckl…

Excited to see the work by Yale Interdepartmental Neuroscience Program students Suzhou Yang Denethi Wijegunawardana w/ collabs Yale Neuroscience iPSC core Joao Pereira Tanina Arab and Mayo Clinic Neuro Tania Gendron Udit Sheth on #C9orf72 #ALS & #FTD finally out in Nature Neuroscience! Wu Tsai Institute | Yale University Yale Kavli Institute for Neuroscience nature.com/articles/s4159…

Nuclear speckle rejuvenation “next frontier” for treating neurodegeneration, via EurekAlert!! eurekalert.org/news-releases/…

Antiparasitic Drug Shows Power Against Alzheimer’s and Dementia today.ucsd.edu/story/antipara…

A multichaperone condensate enhances protein folding in the endoplasmic reticulum: nature.com/articles/s4155…

Academic scientists complain often about the hardship of their chosen career, but in reality research in academia is among the best jobs in the universe. I am at the end of my career, and here are my reasons why I would do it again any day:

I completely agree.

Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation Nature Cell Biology, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵 rdcu.be/eBwPJ

LYVAC/PDZD8 is a lysosomal vacuolator | Science science.org/doi/10.1126/sc…

GraphVelo allows for accurate inference of multimodal velocities and molecular mechanisms for single cells | Nature Communications nature.com/articles/s4146…