As part of our first entry into the Twitter world, we are happy to present our first preprint!

We are hiring!!! Please RT: A postdoc position is now open in our growing lab Nitzan Shabek (UC Davis California) to study the structure-function of hormone signaling pathway and the ubiquitin system. #structuralbiology #postdocjobs #ubiquitin #Biochemistry #plantbiology

Finally! Many thanks to my Ph.D. supervisor Dr. Xinzheng Zhang and my labmate Ph.D. candidate Chunling Wu. Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames cup.org/3hg2bxN

Open-state structure and pore gating mechanism of the cardiac sodium channel cell.com/cell/fulltext/…

Welcome, two new postdocs Songwen and Mark joined our lab!

We now formally define #molecularglue after coining the term for the MoA of #auxin in 2007. nature.com/articles/s4146…

Together with labs of Brian Liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. biorxiv.org/content/10.110…

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…

Together with Michele Pagano's lab at NYU, we are excited to share a new story on two F-box protein E3 ligases recognizing two distinct & mutually exclusive degrons encrypted in the quaternary structure of the substrate protein biorxiv.org/content/10.110…