A7. 1. To our knowledge, our data are novel and contribute new molecular mechanisms linking Rho kinase, ER and oxidative stress through Notch3, as processes underlying vascular damage in PH. I don't think our data contradict previous studies. #HypHIP

A7.2. What is really interesting is that a mutation that causes CADASIL (a small vessel disease of the brain) is also implicated in small vessel injury in PH. #HypHIP

A8.1. We did not encounter any specific experimental challenges, but recognise we have a lot more work to do. For example, we will study the newNotch3-dependent mechanisms in female mice, especially since PAH is more prevalent in women #HypHIP

A8.2. What is especially exciting is that some of the abnormal Notch3-related pathways we identified may be targets for new therapies, eg. - inhibiting Rho kinase with fasudil (which is used clinically, especially in Japan for subarachnoid hemorrhage) #HypHIP

A8.3. So much more exciting work to be done to learn more about Notch3 and small vessel disease, beyond CADASIL. Thanks so much for the opportunity to highlight our study #HypHIP

🔓 For a limited time until August 21, we are offering free promotional access to read the covering editorial for the newest issue of #CJC! 👇 Aging, through knowledge and wisdom: onlinecjc.ca/article/S0828-… 🌐

Rosa Maria Bruno 🔦how the new European Society of Cardiology 2024 ESC Guidelines for Mgt of Elevated #BloodPressure & #Hypertension recommendations for when to start drug treatment & new BP treatment targets ♥️ infographics which can be posted on clinic & waiting rooms etc John William McEvoy @labtouyz

The greatest compliment: freshly released #ESCHypertension guidelines are not boring😎thank you Vass Vassiliou ! John William McEvoy Cian McCarthy The Touyz Lab European Society of Cardiology Dr Anastasia Mihailidou FAHA FCSANZ FESC #ESCCongress

#Hypertension24 - The Touyz Lab from Research Institute of the MUHC (The Institute) presented their latest data from Guto Montezano showing how Notch3 in VSMCs regulates adipocyte-vasculature interactome. Raquel D. Sarafian AHAMeetings AHA Science Hypertension Council on Hypertension Leducq CardioBAT

UVA Researchers Hope To Flip the Switch on Blood Pressure Control news.virginia.edu/content/uva-re… ahajournals.org/doi/10.1161/HY…

🚨Please join me, Guto Montezano Tanja Dudenbostel, MD, FASH, FAHA Carmen De Miguel, PhD, MS, FAHA Francisco Rios next wk fr Hypertension #HYPHIP Author chat which is 🌟 First author publication for Eileen Kaur 👏👏 A First for #Hypertension & possibly most #CardioEd journals - Eileen is still completing her high

Hope that you will join our AHA Science Hypertension #HypHIP Live Chat with 💫💫 authors Eileen Kaur & Kuni Matsushita on the 🚨topic of #BloodPressure arm cuff size & implications for 🇺🇸 adult detection & management of #Hypertension

Thank you Prof Francine Marques 10 brilliant women in STEM! Pick it up, keep moving and follow these women👇 Dr. Kristen Zuloaga @jenpluznick Dr. Michelle Gumz Holly Ingraham Licy Yanes Cardozo Lacy Alexander Eleanor Lederer @DrDeidraCrews M L Sequeira-Lopez The Touyz Lab

CORRECTION this #HYPHIP chat will start in 2.5h. Hope to see you there. Dr Anastasia Mihailidou FAHA FCSANZ FESC Guto Montezano Carmen De Miguel, PhD, MS, FAHA Tanja Dudenbostel, MD, FASH, FAHA Hypertension

In a few minutes, we will start the #HYPHIP Hypertension chat with the author Yixi Sun . We will discuss how metabolomic approach can help to understand hypertension development. AHA Science

This study assesses current global ozone pollution and reveals significant O₃-related health risks, with key focuses on population exposure and all-cause mortality burden, using the high-resolution estimation from a geo-ensemble learning model nature.com/articles/s4146…

Congratulations to Research Institute of the MUHC (The Institute) CHALProgram researchers Dr. Daskalopoulou, Dr. Mavrakanas, Dr. Pilote, Dr. Sharma and Dr. Touyz for their successful CIHR 2024 Fall applications. Dr. Louise Pilote DREAM-CV LAB The Touyz Lab rimuhc.ca/fr/-/resultats… #grants #research

At THE INSTITUTE @rimuhc Research Institute of the MUHC (The Institute), I am passionate about cardiovascular research and medicine and my quest to unravel molecular mechanisms of hypertension. The Touyz Lab CHALProgram EACARE_RI-MUHC

Dr Rhian Touyz and her team have identified a previously unrecognized interaction between Ang-(1-7) and Endothelin-1. The Touyz Lab Read more about the discovery here: rimuhc.ca/en/-/how-blood… #research #cardiology

!Register today! ahajrnls.org/3RGLjlT to join mods Dr Anastasia Mihailidou FAHA FCSANZ FESC Guto Montezano @carmendemigue12 for a Hypertension #HTNImpact Webinar! May 14, 2025 3pm – 4pm CT Under Pressure for Accurate BP Measurement – in Human & Animal Models