In this narrative review at Journal of Neurochemistry I propose that independent misfolding subdomains in PrP of different host species support prion diversity lacking any universally conserved conformational motifs across those species. Check it out! onlinelibrary.wiley.com/doi/full/10.11…

This may be the structural basis for interspecies transmission barriers, but it also suggests that these barriers are not absolute, and can be overcome.

Thanks ⁦International Society for Neurochemistry (ISN)⁩ for the shoutout and great summary! linkedin.com/posts/internat…

Brill

12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak

Apply by 18 May 2025! mankalab.org/blog/fully-fun…

We developed a new siRNA drug candidate for prion disease, a Broad Institute / RNA Therapeutics Institute collaboration. We now have an open IND meaning FDA has given us permission to start first-in-human trials. Work remains before trials can launch. The full update: cureffi.org/2025/04/14/ope…

Recently out! An awesome commentary on our bacterial ESCRT-III work rdcu.be/ei98N - big thanks to John McCullough and Wes Sundquist for this. And of course big shout out to #NSMB for the tasty cover!

So glad to be invited to speak at the FASEB Protein Aggregation: Polymorphic Species conference - a real privilege to be among such thoughtful voices. Thank you for having me and I am looking forward to the conversations. events.faseb.org/event/protein-…

mankalab.org/blog/welcoming…

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We're hiring for a Head of Department to lead one of Europe’s largest and most impactful centres for infectious disease research — right here at Imperial College London. We're looking for a strategic leader with vision and drive. Apply by 15 September👇 imperial.ac.uk/jobs/search-jo…

Please RT 🙏 If you’re an ECR working in the fields of structural or synthetic biology wishing to start your lab then come join us at Imperial, London. We’re looking to support outstanding individuals for external Career Development Awards/Fellowships imperial.ac.uk/media/imperial…

MOSAIC lattice light sheet xy projection over 2+ hrs in human retinal pigment epithelial cells of endoplasmic reticulum remodeling (cyan) and transport of vesicles (yellow) containing β4-galactosyltransferase....

As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET: “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science science.org/doi/10.1126/sc…

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Plausible