A new genome-wide #CRISPR screen identifies BACE1 as a driver of lung cancer #metastasis to the brain, suggesting that BACE1 inhibitors could be repurposed to prevent brain metastasis in #NSCLC. Sheila Singh Brain Tumour Lab McMaster Surgery scim.ag/4eyJwtG

BREAKING: We uncovered a potent immune alliance that could change how we treat solid tumors. Published in Cancer Cell , we show that Th17 cells *must* work with B cells to eliminate tumors—and keep it from coming back. 📄 cell.com/cancer-cell/fu… 🧵1/12👇Let’s walk through it:

Congrats to all on a labor of love. I recall "pd-1 is boring" as a grant review comment. Not so boring in fact... nature.com/articles/s4159…

New preprint from Hemann lab Koch Institute at MIT In vivo screening reveals cell-intrinsic mediators of solid tumor resistance to CAR T cell-therapy biorxiv.org/content/10.110… CRISPR screens in #PancreaticCancer model identifies Nrf2 hyperactivity as a sensitizer to CAR-T cell therapy.

🚨 First paper from the Bocchi lab out now in Nature Communications! We show that astrocytes in the cortex arise from not one, but two distinct progenitor lineages, each giving rise to specialized subtypes with distinct roles. Here the story📖 doi.org/10.1038/s41467… See 🧵below for more.

Qdaisat, Wummer, and Stover et al. demonstrated that early type-I interferon responses restored a defective damage response in poorly immunogenic tumors to enable epitope spreading and sensitivity to ICB. bit.ly/4ojxAk6  UF Health Cancer Center

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors nature.com/articles/s4158…

🚨 Major win for the brain cancer community. The first & only FDA-approved treatment for recurrent H3 K27M-mutant diffuse midline glioma is now a reality. Huge kudos to Jazz Pharmaceuticals and every family, researcher, & patient who got them here. Progress is possible. 💪🧠

Curious about how tumors outsmart the immune system – and what that means for #cancervaccines? Our latest review in 𝐍𝐚𝐭𝐮𝐫𝐞 𝐑𝐞𝐯𝐢𝐞𝐰𝐬 𝐈𝐦𝐦𝐮𝐧𝐨𝐥𝐨𝐠𝐲 takes you behind the scenes: 🔗 nature.com/articles/s4157… or 🔗 rdcu.be/ezRK9

Preclinical Efficacy of Multi-targeting mRNA-based CAR T Cell Therapy in Resection Models of Glioblastoma dlvr.it/TMRL7C #MTNA

🚨More cytokine-signaling magic from the Anusha Kalbasi and Garcia labs. Non-natural signal pairing with the common gamma chain receptor can drive unique transcriptional programs in T cells. 🤯This includes induction of phagocytic T cells by pairing with GSCFR!! rdcu.be/eACzg

Excited to share our nature papers exploiting the receptor pairing code to expand the cytokine receptor alphabet in T cells. Nonnatual receptors reprograms T cells into myeloid lineage. Grateful for the amazing collaborators Anusha Kalbasi , Masato OGISHI

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. biorxiv.org/content/10.110…

Our new method is out in NAR! Need a way to separate cells with point mutation from WT? And run these cells through scRNA-seq or CUT&Tag? Try our STAR-FACS! We separated GBM TERT promoter mutant cells from WT here: academic.oup.com/nar/article/53…

👇Check out new Review article Nature Cancer on cancer nanotechnology by Betty Kim and colleagues doi.org/10.1038/s43018…

Fascinating new paper today in nature from UCL reveals how glioblastomas fuel their own growth by damaging nearby axons—triggering Wallerian degeneration and neuroinflammation. Disabling a key enzyme SARM1 breaks the vicious cycle, slowing tumor progression and extending

Super cool story and science! Congrats Shawn Gillespie Yoon Seok Kim Michelle Monje🎗️ 🟦 and team!

Amazing nature paper by moran amit & the MD Anderson Cancer Center cancer neuroscience team. Cancer is a wound that does not heal but now we learn that injury phenomenon also extends to nerves! Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy nature.com/articles/s4158…

Big announcement: I’m starting a lab at City of Hope in the Department of Diabetes Immunology this October! Huge thanks to UF Diabetes Institute Todd M. Brusko for the mentorship and support without which I could not have achieved this dream of mine. Recruiting lab members soon!