De novo designed pMHC binders facilitate T cell induced killing of cancer cells biorxiv.org/cgi/content/sh… #biorxiv_immuno

🚀 Precision Cancer Immunotherapy with AI-Designed pMHC Binders 🧬 In collaboration with DTU Bioengineering, @DTUHealthTech, and Scripps Research, we developed a de novo binder design pipeline for #pMHCs biorxiv.org/content/10.110…

Application of generative AI for de novo construction of binders to peptide/HLA complexes. Very clever structural solution to overcoming the limitations of de novo TCR design. DTU biorxiv.org/content/10.110…

De novo designed pMHC binders facilitate T cell induced killing of cancer cells 1. This study presents a novel approach to cancer immunotherapy by using de novo-designed peptide-major histocompatibility complex (pMHC) binders to enable precise T cell-mediated killing of cancer

🎄Just in time for the holidays! Leucine zipper-based purification of CAR-T cells displaying multiple receptors (aka Zip-sort). Congrats to Scott James Marcel van den Brink and co-authors! Parker Institute for Cancer Immunotherapy MSK Department of Medicine Memorial Sloan Kettering Cancer Center City of Hope #Tcellpower rdcu.be/d4AX5

Amazing work Tim!

Super cool mechanism of a TCR-pMHC interaction from the great Klebanoff_Lab

Check out these awesome positions in AI protein design with my close friend and collaborator Timothy Jenkins.

Woooow! Such a cool story. Congrats Rahul! Remember the early days of the project - congrats on filing in all the unanswered questions!

Very cool solution to a big technical challenge in T cell immunology!

A functionally validated TCR-pMHC database for TCR specificity model development biorxiv.org/content/10.110… #biorxiv_immuno

AffinityAI Designing binders instead of screening for months? Can’t wait to disappoint reviewers in new and innovative ways.

Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in Science Magazine! We used generative AI to build a 'GPS' for immune cells to hunt cancer. Read it here: doi.org/10.1126/scienc…

How can artificial intelligence design completely new proteins to help T cells better recognize and kill cancer cells?Science Magazine DTU "De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells" • Researchers developed a rapid de novo

👉Check out a commentary in The Scientist which features our take on these three amazing papers! the-scientist.com/an-ai-generate…