Protective tissue resident memory cells in the kidney may also contribute to #autoimmune disease, found past research from CKLab scientists. Check out the findings: scim.ag/JW #WeekendReads

Rethink the #complementsystem in nephrology and enjoy beautiful Hamburg! Join the Freiwald lab at the University Center Hamburg-Eppendorf HCKH_Hamburg UKE Hamburg. BMBF-funded positions for PhD, Post-doc and Technician. Get in touch at freiwaldlab.com.

Beautiful translational work from my friends CKLab : Characterization of pathogenic granzyme B-producing CD8+ T cells in crescentig GN! 💪🏻💪🏻💪🏻

Novel work from HCKH_Hamburg - the role of clonally expanded, granzyme B-producing cytotoxic T cells in ANCA and experimental crescentic GN! Congrats to all authors CKLab Yu Zhao Tobias B. Huber @DrSchwesinger

Hamburg T cell news III: Translational work identifying the GM-CSF–MMP12 axis as a promising therapeutic target for glomerulonephritis. Work led by HJ Paust, Burkhard Becher, Christian Krebs and Ulf Panzer. CKLab HCKH_Hamburg UKE Hamburg pubmed.ncbi.nlm.nih.gov/36921033/

Reminder: we maintain a calendar of worldwide events relevant to glomerular medicine! You can add the whole thing on your own calendar, download details for any event, and/or submit your events! is-gd.org/calendar-of-gl…

Th17 cells from crescentic glomerulonephritis kidneys seed the intestine after transfer. Th17 cells from the gut migrate into crescentic GN kidneys, dependent on S1PR1. Gut-Kidney axis! #inmice Krebs et al 2016 Immunity UKE Hamburg doi.org/10.1016/j.immu…

CKLab Congrats to the fantastic work science.org/doi/10.1126/sc…

Science Immunology has just published our pooled in vivo CRISPR-screen (iCROP-seq). In this study we also address T cell plasticity in the kidney of ANCA-GN patients. Thanks to everybody involved in this study! science.org/doi/10.1126/sc…

Hamburg news: The ⁦CKLab⁩ and collaborators used iCROP-seq to identify TH17 cell plasticity as a potential new therapeutic target in autoimmunity. ⁦HCKH_Hamburg⁩ ⁦UKE Hamburg⁩ ⁦Universität Hamburg⁩ science.org/doi/10.1126/sc…

Happy to be involved in this study. nature.com/articles/s4146… CKLab Stefan Bonn

Hamburg news: Our research from teams CKLab plus Ulf Panzer, and collaborators identify pathogenic T cells in ANCA-associated vasculitis as a target for treatment. HCKH_Hamburg UKE Hamburg Universität Hamburg pubmed.ncbi.nlm.nih.gov/39300109/

Based on our spatial analysis from the kidney at the UKE Hamburg #HCTI HCKH_Hamburg we highlight ustekinumab as a promising new therapy for ANCA glomerulonephritis. Thanks to all involved in this project! nature.com/articles/s4146…

🗨️ WANNA TALK TO YOUR CELLS? Try out CellWhisperer – our new multimodal AI that turns single-cell RNA-seq analysis into a conversation. No coding needed, just chat in plain English. Short walkthrough below. Web app & bioRxiv preprint linked in the thread. Let's dive in! (1/9)

Yang Li, Gaffen @SLG1717 et al. show that IL-17–dependent renal #autoimmunity is driven by Arid5a at the level of ribosome interactions and translation. hubs.la/Q02TJtjq0 📘 In our #Cytokines collection: hubs.la/Q02TJF300 #cytokines2024

Neue Studie zeigt: Das Medikament Ustekinumab verbessert die #Nierenfunktion bei schwerer ANCA-assoziierter Glomerulonephritis (ANCA-GN). Ein wichtiger Fortschritt in der Behandlung dieser lebensbedrohlichen Erkrankung. -> nature.com/articles/s4146…

Excellent vasculitis sessions at #ASNKidneyWeek American Society of Nephrology To immerse yourself in all forms of #vasculitis to learn and work collaboratively across disciplines come to Melbourne - Feb 2026 - for the 22nd Int Vasculitis Workshop. Register your interest at vasculitis-melbourne2026.com

Thank you for sharing this 👍. And well done, Jonas!

Léon-Lara, Sarina Ravens et al. define age-driven postnatal adaptation of γδ T cells and identify CD83⁺ γδ T cells in preterm infants with #sepsis. hubs.la/Q02_5qMl0 📘 From the Year in Experimental Medicine: hubs.la/Q02_5lmt0

Happy to share our new preprint on the #singlecell spatio-temporal progression of glomerular crescents in patients with autoimmune kidney disease from the @UKEhamburg #HCTI: biorxiv.org/cgi/content/sh….