New preprint from our lab @NCIResearchCtr on #AMR in #MRSA #Saureus - we saw some surprising and cool results in this study led by postdoc pavan silva ! biorxiv.org/content/10.110… A short🧵about our findings: 1/7

x.com/AnuKhareLab/st… Happy to see out hard work finally getting published!

Important research out now in Nature Communications from Anupama Khare et al. 💫 Efflux pump SdrM underpins the evolution of #resistance to fourth-generation fluoroquinolone antibiotic delafloxacin in Staphylococcus aureus 🧩💊🦠 (🧵 1/5) nature.com/articles/s4146…

‘By 2050, not only will AMR perhaps be responsible for 10 million deaths annually it will cost the global economy over $100 trillion—this dwarfs the impact of COVID-19 and emphasize the urgent threat of AMR’ journals.plos.org/plosmedicine/a…

Fun fact: #Staphylococcus aureus divides using alternating division planes that are orthogonal to the previous one. But how? But why? @felixrl_, @braf_phd and collabs may have cracked this 50-y.o. mystery! #MRSA Our preprint: biorxiv.org/content/10.110…

Super cool research out in Nature Communications 🤩 Multicopy plasmids, often carrying antibiotic #resistance genes, can rapidly amplify genes, leading to transient antibiotic resistance 🦠💊 nature.com/articles/s4146…

Phenotypic heterogeneity is generated by passive mechanisms like noise in gene expression, right? Not always! Check out an ACTIVE mechanism for generating diversity in a clonal bacterial population: biorxiv.org/cgi/content/sh…

Publication alert 🚨: Our new review article on antibiotic resistance via distinct gene amplifications is out now in npj antimicrobials and resistance!!! Here is the link: nature.com/articles/s4425… #antibioticresistance #geneamplification

Antibiotic resistance mediated by gene amplifications🧬 This review is available open-access to read npj Antimicrobials and Resistance! pavan silva Anupama Khare (1/5) nature.com/articles/s4425…

Check out our new work on identifying the genes involved in the formation and maintenance of gene amplifications in Staphylococcus aureus. Anupama Khare