nature.com/articles/s4146… #polycistronic #IRES #P2A #IGG #HACKing a 9 nucleotide sequence (IGG6) enables efficient polycistronic gene expression in yeast and filamentous fungi. This is more efficient than using IRES sequences, and does not add extra amino acids like 2A peptides

Like ChatGPT, but for #mRNA design! CodonBERT is a large language model from @Sanofi , trained on millions of mRNA ORFs across diverse organisms. The model improves the prediction of mRNA properties. biorxiv.org/content/10.110…

We are thrilled to share our manuscript ‘An RNA foundation model enables discovery of disease mechanisms and candidate therapeutics’ as a preprint! 🧵 biorxiv.org/content/10.110…

One of the fantastic bacterial defense systems #phage #Bil #Ubiquitin

High-Complexity One-Pot Golden Gate Assembly from New England Biolabs …rentprotocols.onlinelibrary.wiley.com/doi/10.1002/cp…

News: SARS-CoV-2 infects coronary arteries, increases plaque inflammation dlvr.it/Swk9k7

Today's a good day to highlight that I recently put together a Cell Press Selection on RNA sensing in immunity, featuring recent papers and reviews from Cell Molecular Cell Trends in Immunology and more: info.cell.com/rna-sensing-in…

This is the link to the study👇 pnas.org/doi/10.1073/pn…

#saRNA #vaccine #covid #innate #RIG-I #5mC #modification one more study of 5mC modification to the innate immune response in self-amplifying vaccine platform biorxiv.org/content/10.110…

pH-dependent structural transitions in cationic ionizable lipid mesophases are critical for lipid nanoparticle function | PNAS pnas.org/doi/10.1073/pn…

Lipid shape and packing are key for optimal design of pH-sensitive mRNA lipid nanoparticles | PNAS pnas.org/doi/10.1073/pn…

A brief summary of mRNA processing. From here, we'll dive down and learn the details of each step. Learn more at smart-biology.com #biology #3D #animation #EdTech #science

1/12 Thursday is #tutorial day! This week, we want to show you how to find out which biological pathways a gene is involved in!

The future of genome editing is in vivo! Check out our latest PNASNews perspective from @doudna_lab. Had a lot of fun discussions with Kevin Wasko and Jennifer R Hamilton about the past, present, and future of in vivo delivery. pnas.org/doi/10.1073/pn…

#delivery #ASO #oligonucleotide therapy: Anisamide-conjugated hairpin antisense oligonucleotides prodrug co-del... sciencedirect.com/science/articl…

#Eclipse2024 #Boston galaxy ultra23 100x and a filed western blot film :)

New research from Universität Jena shows that 18-nucleotide primers significantly improve #RNA transcript detection, enhancing accuracy in research and diagnostics. #RNAseq #Genomics rna-seqblog.com/exploring-the-…

dual-capped mRNA and capped circular RNA --> 17-fold and 3.7-fold higher antibody production, respectively.

Peptide nucleic acid-mediated circularization of target RNA as tool to inhibit translation. doi.org/10.1016/j.ijbi… #ASO #PNA #Antisense #oligonucleotides #translation #inhibitor