Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry. 🙏 RETWEET (We want to recruit internationally) Organic chemistry meets #DirectedEvolution Highly interdisciplinary & passionate research group uni-bielefeld.hr4you.org/job/view/4339/…

タンパクの配列から音楽を奏でるというぶっ飛んだパフォーマンスでBIOTRANS2025の幕があけました

Thrilled to share our latest paper just out in J. Am. Chem. Soc.! We uncovered an unprecedented KS domain-catalyzed β-lactonization in the biosynthesis of the HMG-CoA synthase inhibitor hymeglusin. Huge congratulations to Mizuki on his first paper! 🎉 pubs.acs.org/doi/10.1021/ja…

The Katsuyama group (A03) discovered the biosynthetic gene cluster for thrazarine, a diazo group-containing amino acid, in actinobacteria and the hydrazine synthase ThzN catalyzing formation of a key intermediate from L-threonine and N6-hydroxylysine. doi.org/10.1002/cbic.2…

Identification of a L‐threonine‐utilizing hydrazine synthetase for thrazarine biosynthesis in Streptomyces coerulescens MH802‐fF5 - Shikai - ChemBioChem - Wiley Online Library …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100…

The Terada group (A02), in collaboration with Dr. Leow (A02), has developed ColabReaction — a cloud-based tool for accelerated transition state searches using Direct MaxFlux (DMF) and the ML potential (UMA) available at: colabreaction.net preprint: chemrxiv.org/engage/chemrxi…

The Oguri group (A03) has established a synthetic strategy that enables scaffold-level redesign of ecteinascidins, unlocking access to potent anticancer macrocycles. available at: cell.com/chem/abstract/… press release: x.gd/wZZmw Chem

Thank you all for making our conference in Fukui a great success! The talks and discussions were fantastic. See you in February at our next symposium at RIKEN, Tokyo!

The Ushimaru group (A01), in collaboration with Prof. Hung-wen Liu, has uncovered a sulfur incorporation mechanism generating the thionucleoside antibiotic albomycin. nature.com/articles/s4192… Nature Catalysis

The Ozaki (A01) group, in collaboration with Prof. Teigo Asai group Asai_lab., demonstrated that the ketosynthase domain of a highly-reducing polyketide synthase catalyzed β-lactone formation in the biosynthesis of hymeglusin. J. Am. Chem. Soc. pubs.acs.org/doi/full/10.10…

The Nakano (A02), Chisuga (A02), Terada (A02) and Kudo (A01) groups in collaboration with Dr. Miyanaga demonstrated that ancestral sequence reconstruction is a tool for structural analysis of modular polyketide synthases. Available at: nature.com/articles/s4146…

渾身の新作論文Nature Communications (doi.org/10.1038/s41467…)です！合成多核金属錯体の構造をタンパク質だけを用いて構築に成功しました。また、人工酵素の多くがテンプレートタンパク質元来の機能と人工機能をトレードオフする中、今回の人工酵素では、内在性機能と外来性機能を両立しています。(1/6)

The Shoji group (A03) has developed a recyclable whole-cell biotransformation system for the direct hydroxylation of propane, catalyzed by a robust intracellular wild-type cytochrome P450BM3 activated by a decoy molecule. JACS Au pubs.acs.org/doi/10.1021/ja…

The Kato (A03) and Shoji (A03) groups developed an efficient system to express active hemoproteins by engineering the heme biosynthesis pathway in E. coli, improving whole-cell and lysate-based biocatalysis using heme enzymes. Angewandte Chemie onlinelibrary.wiley.com/doi/10.1002/an…

The Takahashi group (A01) reported the regulator-driven discovery of bioactive elasnins and antimycins from engineered Streptomyces. doi.org/10.1021/acsome…

The Takahashi group (A01) determined the co-crystal structure of drimenol synthase, revealing that its TCβ domain catalyzes class II cyclization and its HAD-like domain performs metal-dependent dephosphorylation. pubs.rsc.org/en/Content/Art… press release: riken.jp/press/2025/202…

The Tsutsumi group (A02) established a strategy combining comparative genomics and metabolomics analyses to rapidly discover natural products, leading to the identification of novel tricyclic peptides lentindoles A & B from Lentzea sp. OK19-0192. ChemEurJ: Chemistry - A European Journal …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch…

Hoshino group (A01) has conducted a functional characterization of late-stage biosynthetic and transporter genes in the biosynthetic gene cluster of the organoarsenic natural product bisenarsan. doi.org/10.1248/cpb.c2…

The Kato group (A03) reports a novel biocatalytic system using N. simplex aldoxime dehydratase. The enzyme efficiently catalyzes abiotic radical ring-opening reaction of non-activated cycloketone oximes with high activity. onlinelibrary.wiley.com/doi/full/10.10…

The Shoji group (A03) has developed a synergistic strategy to construct a metal-responsive cyclic protein assembly by integrating generative protein design with synthetic porphyrin chemistry. | published in Small doi.org/10.1002/smll.2…