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Escaping US election jitters in the Antipodes, with two of my #science #heroes 🤩🤩 Mark Dawson @FendtLab

Our very own @ManishaRaghavan GSK Graduate School Karuna Ganesh Lab flexing her communication skills and expertly interviewing former PepsiCo CEO Indra Nooyi 👏👏👏

Thank you ⁦Elena Kotsiliti⁩ ⁦Nature Reviews Gastroenterology & Hepatology⁩ for highlighting our recent ⁦nature⁩ paper 👇🏽👇🏽👇🏽 nature.com/articles/s4157…

Excited to share our latest work in Immunity led by our own Siyu Sun The Halvorsen Center for Computational Oncology Memorial Sloan Kettering Cancer Center, who tried to assemble the puzzle of how cancer cells and cancer-immune interactions co-evolve with the retrotransposons of the #DarkGenome! With Eunae You, Sasha Solovyov,

Great story from Tuomas Tammela Xueqian Zhuang and team on lung stem cell ageing and declining tumorigenic fitness. Congratulations!

This graph of annual percentage change in incidence of young onset #ColorectalCancer versus the rest of the age groups always blows my mind. Something societal changed in the mid to late 70s and EOCRC started manifesting in mid-80s onwards. And just kept going…..

biorxiv.org/content/10.110…. Aberrations in epigenetic regulation prevent cellular differentiation and endow plasticity to cancer. By screening drugs using a new reporter system, we found that inhibiting HDAC1/2 promotes colorectal cancer (CRC) differentiation and anti-tumor activity

Congratulations Thomas Norman #perturbseq experts on this exciting paper!

1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇 nature.com/articles/s4158…

2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to fetal progenitor states, driving squamous & neuroendocrine traits linked to poor outcomes. Karuna Ganesh Memorial Sloan Kettering Cancer Center nature.com/articles/s4158…

Metastasis accounts for most cancer deaths. A new study from Damon Runyon alum Karuna Ganesh reveals why metastatic tumors are so much harder to treat than primary tumors—and how the process of metastasis may be curbed. Read more: bit.ly/4iW0fZz

Congratulations Samra and team! Exciting work on non-genetic tumor evolution in metastasis, here in ccRCC 👇🏽👇🏽👇🏽

Congratulations Mara Sherman Lab and other winners!

No better feeling than seeing trainees do brilliantly. Super proud of Qingwen! Stay tuned for her work…. #proudPI

Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏾💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Cancer Discovery aacrjournals.org/cancerdiscover…

Some great news: incredibly proud of our Medical Oncology Fellow Jaeyop Lee MD, PhD comentored by David Scheinberg, who just received the NoA for an NCI K99/R00 award!!! Stay tuned for his groundbreaking work on CRC immunotherapy Karuna Ganesh Lab MSK Department of Medicine Memorial Sloan Kettering Cancer Center

Congratulations Yael David and team! Gorgeous science

📷 #preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud Weill Cornell GSMS HHMI biorxiv.org/content/10.110…

Congratulations Stefanie

Kevin Boehm Stefanie Gerstberger, MD PhD 3/3 Dr. Stefanie Gerstberger, a third-year medical oncology fellow and postdoc researcher in the lab of Karuna Ganesh, investigates #phenotypic #plasticity and chemo resistance in #colorectalcancer. She's also awarded the AACR Women in Cancer Research Scholar Award. #AACR25 Learn