extremely normal times I see

Plasmid-based reporter assays are the bedrock of regulatory genomics. But a basic question has gone unanswered for decades: Do chromatin architectures form on plasmids transfected into mammalian cells—and does it matter? We finally have answers. biorxiv.org/content/10.110…

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…

Today in nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a

I’m going to rewrite all my best papers and call them Sri’s version to regain copyright control.

Manifold Bio has a new look! And we're hiring! Checkout the careers page at manifold dot bio.

Endometriosis is an incredibly interesting disease 5k words, 23 minutes reading time covering one of the strangest conditions ive ever heard about link: owlposting.com/p/endometriosi… very grateful to Shilpa Pothapragada for initial inspiration for this piece + reviewing it!!

watching my partner be a dad these past 16 months has been the greatest joy of my life. happy Father's Day Pierce

One thing that really bothers me with the new "virtual cell" terminology is that is currently largely focused on a very narrow definition of models that can predict effects of trans perturbations (gene dosage, drugs etc) on gene expression. 1/

Doing a postdoc to get a tenure-track faculty position

More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…

tell me you're writing a review without telling me you're writing a review

getting weirder and weirder to show up at work every day as a researcher at a university and pretend we're not witnessing the active dismantling of American research universities

We're live! Manifold Bio's new website is here: manifold.bio Inspired? We're growing—join us. Special thanks to Bunsen for articulating our vision and Javelin Tea Creative (javelinteacreative.com) for capturing the spirit of our team. #Hiring

New ENCODE4 long-read RNA-seq transcripts track for hg38 and mm10. Triplets (e.g. [1,1,3]) indicate start site, exon combination, and stop site for each transcript. Enrichment scores show how these change across tissue and cell line samples. Read more: genome.ucsc.edu/goldenPath/new…

unreasonably sad that Aliquots, our building cafe with an incredible name and decent donuts, closed for good unceremoniously 😭 it's been a reliable snack source for me for 11 years and it's just.... boarded up!!

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in nature! 🧵below nature.com/articles/s4158…