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You can't do genetics without the involvement of patients and their families! A special thanks to those who have gotten involved in our NIH-sponsored studies on hydrocephalus, vein of Galen malformation, and others. THANK YOU - and blessings for health and joy in 2020!

A new paper in World Neurosurgery Journal explores the challenges faced by teens w/ #hydrocephalus when transitioning from pediatric to adult health care & highlights the recommendations that came out of HA’s Transition Summit. Read it for free for a short time! bit.ly/39aSRVO

Motile cilia not primarily as CSF propellers but transducers of neural stem cell fate signals? Relevance for kids with hydrocephalus (and other disorders). Nice job ⁦Duy Phan MD, PhD⁩! ⁦Kahle Laboratory⁩ ⁦MGH Neurosurgery⁩ ⁦Broad Institute⁩ sciencedirect.com/science/articl…

Genomic basis for the most common space-occupying brain lesion in humans. Congrats to Adam and other ⁦Kahle Laboratory⁩ team members and ⁦GeneDx⁩ and ⁦Sheng Chih Jin⁩. Thanks to patients and their families! ⁦@MGH_RI⁩ ⁦MGH Neurosurgery⁩ nature.com/articles/s4159…

Congratulations to all team members behind this publication in Cell regarding the molecular mechanism of acquired hydrocephalus and resultant treatment considerations. MGH Neurosurgery @MGH_RI Boston Children's Broad Institute massgeneral.org/news/press-rel…

Multi-omic analyses reveal de novo variants causing genetic neurodevelopmental conditions in up to 16% of cases of patients with cerebral arachnoid cysts, suggesting that surgery may not improve non-mass effect related symptoms Kahle Laboratory Adam Kundishora, MD nature.com/articles/s4159…

Excellent talk by Dr Kristopher Kahle of MGH Neurosurgery on the utility of multi-omics in clustering and managing neurosurgical diseases like congenital hydrocephalus. Omics may be our generation’s surgical microscope Kahle Laboratory

Congenital Hydrocephalus patients & families, Join our NIH-sponsored study on discovering new genes in Hydrocephalus! Participation is free and easy. To get involved or learn more, visit: kahlelab.com/join-study Kristopher Kahle, MD, PhD [email protected]

Vein of Galen Malformation patients & families, Join our NIH-sponsored study on discovering new genes in VOGM! Participation is free and easy. To get involved or learn more, visit: kahlelab.com/join-study Kristopher Kahle, MD, PhD [email protected]

Moyamoya Disease patients & families, Join our NIH-sponsored study on discovering new genes in MMD! Participation does not require travel- it's free and easy. To get involved or learn more, visit: kahlelab.com/join-study Kristopher Kahle, MD, PhD [email protected]

Overwhelmed with gratitude for the four young men from Kahle Laboratory who matched today in neurosurgery - Tyrone DeSpenza (Duke Neurosurgery ), Ben Reeves (BarrowNeurological ), Emre Kızıltuğ (Michigan Neurosurgery), and @kedousmekbib (Mayo Clinic Neuro). I couldn’t be more proud+thankful for these soldiers!

Congrats to ⁦Kahle Laboratory⁩ class of 2024 - Ben Reeves, Tyrone DeSpenza, ⁦@kedousmekbib⁩, and ⁦Emre Kızıltuğ⁩ - moving on to bigger and better things: neurosurgery residency! Thank you gentlemen! ⁦Yale School of Medicine⁩ ⁦Yale Department of Neurosurgery⁩ ⁦MGH Neurosurgery⁩