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Pretty cool that ⁦Kahle Laboratory⁩ alumna Amrita Singh can find a novel human disease gene, SMARCC1 - making the cover of Brain - while a neurosurgery intern ⁦Columbia Neurosurgery⁩. True grit! Thanks Sheng Chih Jin⁩ and Engin Deniz lab ⁦Yale School of Medicine⁩. ⁦MGH Neurosurgery⁩

Congrats Kahle Laboratory star Emre Kızıltuğ on this fantastic collaboration with Jennifer Strahle, MD and her lab. Emre will be taking his talents to neurosurgery residency at UMichigan in a couple short months, and he is still banging it out in the meantime. Integrity. Big story below!

PGY-1 Resident, Amrita Singh, MD, published a groundbreaking paper in #Brain (@oupacademic) on gene discovery for congenital #hydrocephalus. 🎉 Her research explores how a novel SMARCC1 gene variant impacts #brain development. 🧠💡 Read more: academic.oup.com/brain/article-…

Congrats to ⁦Kahle Laboratory⁩ class of 2024 - Ben Reeves, Tyrone DeSpenza, ⁦@kedousmekbib⁩, and ⁦Emre Kızıltuğ⁩ - moving on to bigger and better things: neurosurgery residency! Thank you gentlemen! ⁦Yale School of Medicine⁩ ⁦Yale Department of Neurosurgery⁩ ⁦MGH Neurosurgery⁩

Great review by ⁦Robert Friedlander⁩ on Chiari malformations! Clinical heterogeneity and variable surgical results will undoubtedly be explained by genomic subtypes - stay tuned! ⁦Bobby Jones Chiari & Syringomyelia Foundation⁩ ⁦MGH Neurosurgery⁩ ⁦Pitt Neurosurgery⁩ nejm.org/doi/full/10.10…

Congrats and immense appreciation to Herb Fuchs, MD, PhD, as he steps down from his role as chief of pediatric neurosurgery (but not from Duke Neurosurgery!) after 32 years of service. Gerald A Grant MD

Nice boost to start your first days of residency ⁦Duke Neurosurgery⁩ with another outstanding paper! Congrats ⁦⁦Kahle Laboratory⁩ alum and Yale MD/PhD prize winner Tyrone DeSpenza. Concurrent examination of cortical function and CSF homeostasis! pnas.org/doi/10.1073/pn…

Excited to announce our latest publication in PNASNews! Amazing team effort and collaboration between Kahle Laboratory and Luikart Lab! We uncover how pathogenic variants in the autism spectrum disorder-associated gene KATNAL2 impact intraventricular CSF homeostasis and parenchymal

The AANS/CNS Joint Section of Pediatric Neurological Surgery Research Committee would like to congratulate Adam Kundishora for being awarded the 2024 Pediatric Section Research Grant.

Nice viewpoint on our recent PNAS paper by DeSpenza et al. - concurrent mutational impact on CSF dynamics and intrinsic brain connectivity. Implications for how we counsel neurosurgical patients. ⁦MGH Neurosurgery⁩ ⁦Duke Neurosurgery⁩ pnas.org/doi/abs/10.107…

Just received NOA for my R01 from NINDS! Huge thanks to Kristopher Kahle, Dave Limbrick, MD, PhD, Hydrocephalus Assoc. for the incredible support. Excited to dive into the molecular & cellular mechanisms of congenital #hydrocephalus w/ Monkol Lek, Andrés Moreno De Luca, MD, MBA, DABR, and the team WashU Medicine Genetics

A clinical trial inspired by our Nat Med 2107/Cell 2023 papers has just begun for hemorrhagic hydrocephalus at one of largest hospitals in China. Thanks to ⁦Hydrocephalus Assoc.⁩ ⁦NIH⁩ ⁦Kahle Laboratory⁩ ⁦Yale Department of Neurosurgery⁩⁦MGH Neurosurgery⁩ clinicaltrials.gov/study/NCT06563…

"If there is no ultimate truth to guide and direct political activity, then ideas and convictions can easily be manipulated for reasons of power…a democracy without values easily turns into open or thinly disguised totalitarianism.” - St. John Paul II, Centesimus Annus (1991).

Congrats ⁦Kahle Laboratory⁩ and ⁦Harvard Medical School⁩ student and future neurosurgeon Neel Mehta for discovering a new human disease gene (LDB1) and impressing folks like my ⁦Boston Children's⁩ mentor Ben Warf and legend Jim Rutka at ⁦ISPNeurosurgery⁩ in Toronto.

Special thanks to ⁦Society of Neurological Surgeons⁩ for the opportunity to speak at this year’s RUNN course in Woods Hole on the use of integrative -omics for elucidating pediatric neurosurgical disease. Nice backdrop to talk with future neurosurgeon-scientist leaders! ⁦AANS/CNS Peds Section⁩

“Christian love is not a concentric expansion of interests that little by little extend to other persons and groups… The true ordo amoris that must be promoted is that which we discover by meditating constantly on the parable of the ‘Good Samaritan.’” commonwealmagazine.org/francis-trump-…

Congrats ⁦Kahle Laboratory⁩ alumni and now neurosurg residents ⁦Tyrone DeSpenza⁩, ⁦Emre Kızıltuğ⁩ and collaborators Bryan Luikart et al. on bringing this to fruition. Hydro mutations impact brain AND drain! ⁦⁦Harvard Medical School⁩ ⁦MassGeneralNeuroscience⁩ nature.com/articles/s4159…

Excited to announce our latest publication! PTEN mutations impact neuroprogenitor cell development leading to altered cortical networks and hydrocephalus. Amazing team effort Kahle Laboratory, Luikart Lab, Emre Kızıltuğ, and all of our incredible co-authors! nature.com/articles/s4159…

Recent events get me thinking about true power: “But mercy is above this sceptered sway; It is enthroned in the hearts of kings, It is an attribute to God himself; And earthly power doth then show likest God's when mercy seasons justice.” -Shakespeare, MofV, Cf. Lk 6:36, Ex 34:6

Congrats to Garrett, Kedous, Evan, and Danielle! Be on the lookout for the paper. Harvard Medical School Mass General Brigham Research Boston Children's AANS CNS