We are pleased to share our structure with the community. PDBs also available!

Our lab has an opening for a postdoc investigating molecular mechanisms of cell cycle regulation using #CryoEM & #CryoET As part of the DCI, we have access to several high-end microscopes. If you’re interested in joining us in lovely Geneva please email to [email protected]

More information can be found here: cryoem.unige.ch ; dci-lausanne.org ; tinyurl.com/425tscxr ;

In collaboration with Janet Iwasa and Julia Brasch (Julia Brasch), we are thrilled to announce that the first chapter of CryoET 101 is officially released! Curious about cryo-ET and if it's the right method for your project? Check it out at cryoem101.org/chapter-1-et/.

Talks for the CCP-EM Spring Symposium 2022 are now available to view, by session at ccpemss.co.uk/schedule/

1/10 The ankyrin complex story from our lab Columbia Vagelos College of Physicians & Surgeons ⬇️ is out now in NatureStructMolBiol, along with a beautiful study by The Zhou Lab and news & views piece by Ash. Congrats to all authors & particularly Francesca Vallese! Read on for developments since the preprint:

Looking forward to this seminar. Thanks for the invitation Kai! Jack Zhang Lab Yale MB&B MB&B Informal Seminar: Andreas Boland, Ph.D. Structural basis of human separase regulation by securin and CDK1-cyclin B1 shar.es/afgH11

Caspases control programmed cell death in eukaryotes. Type III-E CRISPR harbors caspase-like proteases. Our new Science paper explains how Craspase switches on protease activity in RNA-guided fashion - safe alternatives to Cas nucleases in therapeutics. science.org/doi/10.1126/sc…

This newly published review by eBIC staff discusses recent examples on how cryoET can be used to study membrane remodelling processes. Find the paper here: doi.org/10.1016/j.sbi.…

Nature research paper: Visualizing translation dynamics at atomic detail inside a bacterial cell go.nature.com/3CiHagN

So excited to have our structure on the B-cell receptor published in Nature online! - thanks to absolutely talented Ying Dong @ying70337209 and Xiong Pi @Sampich4 nature.com/articles/s4158…

Thanks for being given the opportunity to present the work from our lab! It is really so much fun here in Konstanz #EMBOcellcycle2022 And thanks for the picture Lina!

Happy to share that our paper is finally out! Loewith lab Panagiotis Kastritis We report the cryo-EM structure of the yeast SEA complex, revealing the interaction between SEACAT (GATOR2) and SEACIT (GATOR1). Video by @cienciagrafica 1/ nature.com/articles/s4158…

Visualizing ligand bias at the Mu-opioid receptor cell.com/cell/fulltext/…

The Boland Andreas Boland & Loewith Loewith lab labs are hiring a joint postdoctoral researcher to work in the field of cell metabolism and physiology. We are looking for someone with strong expertise in cryoET and single particle analysis. Dubochet Center for Imaging (DCI) Please spread the word! 🙏

Below is a link to Jun Yu's jun review on human separase regulation. portlandpress.com/biochemsoctran… We summarise recent structural and functional data on separase inhibition, and discuss new ideas how phosphorylation of separase and its substrates may control protease activity.

The molecular mechanisms of human separase regulation dlvr.it/SnXTJ0

Results from new detector for THERMO FISHER-SCI Tundra #CryoEM . Do I see some donuts? Join us on 7/13 at ter.li/vbj3dn to hear more about how we did it. Movie credit lingboyu

🚨Paper alert🚨 Our new work on APC/C regulation revealed by high resolution cryo-EM structures together with the groups of Leifu Chang and David Barford. Congratulations to Anna Höfler, Jun Yu and all other authors. The manuscript can be found here: biorxiv.org/content/10.110…

Today is the second anniversary of DCI-Lausanne, and we're thrilled to share the incredible news: Our amazing team (especially Sergey and Inay), has just gifted us with the extraordinary achievement of a 1.12A ApoF structure from the Titan without an energy filter! 🚀 Dubochet Center for Imaging (DCI)