Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins dlvr.it/TLCTwq

🧵1/ Excited to share my first publication from the ColonnaLab in Nature Immunology! We investigated how mutations in the human CSF1R gene disrupt microglia and impair white matter integrity in a rare but devastating neurodegeneration called ALSP. nature.com/articles/s4159…

Jean Paul Chadarevian, PhD, a researcher in the Blurton-Jones Lab, was recently awarded the Tom Angell Fellowship Postdoctoral Scholar Award

CSF1R inhibitor-resistant model for CNS-wide microglia replacement strategies dlvr.it/TPDM43 #genetherapy #celltherapy

Microglia replacement via vascular delivery and no toxic preconditioning? Now THAT is something I can get excited about. In our new paper we find that microglia replacement can now be achieved by peripheral delivery w/ no irradiation or chemo required. 👉 doi.org/10.1016/j.ymth…

Excited to share our most recent work from Blurton-Jones Lab “ Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo” - Coburn - Eskandari-Sedighi, 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Human microglia differentially respond to β‐amyloid, tau, and combined Alzheimer's disease pathologies in vivo alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… Alzheimer's & Dementia Journals

Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer’s disease | Science Translational Medicine science.org/doi/10.1126/sc…