VISTA immune checkpoint blunts radiotherapy-induced antitumor immune response Cell Reports Dhanya Nambiar Quynh Thu Le cell.com/cell-reports/f…

Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons | PNAS pnas.org/doi/10.1073/pn…

A new Science #Immunology study demonstrates that loss of the ubiquitin ligase #Riplet induces terminal exhaustion of CD8 #Tcells and promotes resistance to anti–PD-1 treatment in mouse models of hepatocellular #carcinoma. scim.ag/4nkicmP

Tumour cells mimic erythroblasts to hijack iron from bone marrow macrophages bit.ly/46jztqc

Images in Clinical Medicine: Cutaneous Extramedullary Plasmacytoma after Bone Fracture nej.md/3HMGYvw #DermTwitter

In the latest video in our partnership with Dr. Glaucomflecken, the REGENCY trial investigating the efficacy and safety of obinutuzumab when added to standard therapy in patients with active proliferative lupus nephritis is explained. Access the article for free:

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging dlvr.it/TLhFdr

Muscle needs NAD, but how much? dlvr.it/TLlbm9

Mammalian tRNA acetylation determines translation efficiency and tRNA quality control nature.com/articles/s4146…

Investigating the Impact of Omental Adipocytes on Ovarian Cancer: Insights from a 3D in-silico model dlvr.it/TLmYMT

Scientists have identified an isoform of the Type2 #cytokine receptor subunit IL13Rα1 that can fine tune immune responses and may underlie varied susceptibility to #allergic disease. The Francis Crick Institute Imperial College London Learn more in Science #Immunology: scim.ag/4ko0Lzh

Online Now: KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer dlvr.it/TLrhCk

New research in mice published in Science #Immunology identifies the Spi-B–c-Kit–TSLP pathway in #TuftCells as a potential therapeutic target to reduce the severity of food #allergies and other type 2 inflammatory disorders. scim.ag/3I4sEyV

Scientists show that paired analysis of #CD69 mRNA and protein levels can help identify potent CD8 T cells with enhanced #cytotoxic effector functions within exhausted populations in tumors. Arja Ray Max Learn more in Science #Immunology: scim.ag/3Ik4aBL

Repurposing of old drugs for unleashing innate immunity dlvr.it/TLsvKS #immunology

In the BATURA phase 3b trial, as-needed albuterol–budesonide resulted in a lower risk of severe asthma exacerbation than as-needed albuterol among participants with disease that was uncontrolled despite treatment for mild asthma. Full trial results and Research Summary:

A new Science #Immunology study identifies CD8 #Tcells with enhanced effector function in tumors, which could be leveraged for #cancer treatments. scim.ag/3Ik4aBL

Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity. Samuel Klein of WUSTLnews reports in Cell Metabolism #ENDO2025 hubs.li/Q03wtLK-0

Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models dlvr.it/TM0Npb

At NOSCM, Julia Rotow MD presents provocative data supporting continuation of EGFR TKIs after progressive disease, so-called treatment beyond progression (TBP). I am increasingly a believer. Invariably there are residual sensitive clones which need to be controlled