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Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome

AF3 server is LIVE! Just tried predicting complex with almost 5K amino acids. TIP: you need to click "continue with google" to access the server (otherwise the "server" is grayed out). alphafoldserver.com

Mapping genotypes to chromatin accessibility profiles in single cells nature.com/articles/s4158… #journals #feedly

The sun is out for Day 3 of #Stemgastro24. Many exciting talks to look forward to with the poster awards & gala dinner this evening 🕺💃

Beyond elated to drop our new hit on the latest Cell Stem Cell album: “Zero to Hero: ERRgamma trains gastric stem cells to be parietal cells”. Using new mouse models and cell lines, we explore how ERRg regulates acid-secreting parietal cells regeneration from stem cells!!

doi.org/10.1038/s41556… live imaging of Kras G12D-driven tumorigenesis in the hair follicle.

Much of the impact of alternative splicing is mediated by nonsense-mediated decay-induced changes in gene expression rather than diversification of the proteome Nature Genetics Yang I Li nature.com/articles/s4158…

Online now: Dual function of PHF16 in reinstating homeostasis of murine intestinal epithelium after crypt regeneration dlvr.it/TCmpN6

Do you know how the injury response is resolved after regeneration? We found a nuclear regulator Phf16 that reinstates homeostasis after tissue regeneration upon intestinal injury. Find more details from the following link: authors.elsevier.com/c/1jiaE5Sx5gxl…

I am greatly honored to be a part of this paper! :)

#Cellsize is important for many cellular processes, including biosynthesis, organelle homeostasis and development. If you need an overview of how cell size is controlled, and how it affects cell function, we have you covered: doi.org/10.1152/physre… Yagya Chadha Arohi Khurana

Super happy to share that our paper is published in nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: bit.ly/3MSxoa1 🏥CCB_VIB_KUL Department of Oncology - KU Leuven The Netherlands Cancer Institute Van Rheenen Lab Benjamin Simons

Thrilled to share our first study on aging from Miriam Merad, MD, PhD lab Icahn School of Medicine at Mount Sinai The Tisch Cancer Institute Lipschultz Precision Immunology Institute in which we demonstrate how aging promotes cancer. We show that: (1/n) science.org/doi/10.1126/sc…

TGF-β and RAS jointly unmask primed enhancers to drive metastasis Cell MassagueLab cell.com/cell/fulltext/…

Tomo Mizutani & Matteo Boretto selected 4 spontaneous colon #cancer mutations by sequential withdrawal of growth factors from mismatch repair-deficient #organoids. Mutations resemble those of Lynch syndrome & MSI-H patients tumors. nature.com/articles/s4301…

Postdoc position in Singapore! RNA modifications and epitranscriptomics for cell fate reprogramming. :) For more details, please visit Jon's lab webpage. 😊 jonlohstemcells.wordpress.com

Thrilled to share that our paper nature.com/articles/s4158… is featured in a fantastic Nature News & Views piece by Thomas Tueting! 🎉 Grateful for the spotlight on our research and its impact on understanding cancer immunology. nature.com/articles/d4158… 👀👉 rdcu.be/d3cRz

Online now: mTor limits autophagy to facilitate cell volume expansion and rapid wound repair in Drosophila embryos dlvr.it/THPHY1

Today in Cell! Scientists at Peking University (Peking University) detailed the spatiotemporal and genetic lineage differentiation of the endoderm at single-cell resolution. 🔎 Discover their findings: bit.ly/3WgY1tZ