Jason Fernandes (@jdf_ev) 's Twitter Profile
Jason Fernandes

@jdf_ev

Head of Epigenetic Engineering @scribetx
Views are my own.

PhD: Overlapping genes w/ Alan Frankel (UCSF)
Postdoc: KZNFs w/ David Haussler (UCSC/HHMI)

ID: 3529742773

calendar_today11-09-2015 19:03:48

3,3K Tweet

716 Followers

1,1K Following

nature (@nature) 's Twitter Profile Photo

Researchers funded by the NIH will be required to make their scientific papers available to read for free as soon as they are published go.nature.com/3Gh7Rr8

Nature Reviews Molecular Cell Biology (@natrevmcb) 's Twitter Profile Photo

New Online! Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease bit.ly/4eDcpov

New Online! Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease bit.ly/4eDcpov
UCSC Genome Browser (@genomebrowser) 's Twitter Profile Photo

We turn 25 today! July 7th marks the 25th anniversary of the human genome going online and the start of the UCSC Genome Browser. Then vs. now, we have 165k monthly visitors, and our codebase is over three million lines of code. See our news for more: bit.ly/genomeBrowser2…

We turn 25 today!

July 7th marks the 25th anniversary of the human genome going online and the start of the UCSC Genome Browser.

Then vs. now, we have 165k monthly visitors, and our codebase is over three million lines of code.

See our news for more: bit.ly/genomeBrowser2…
No Patient Left Behind (@nplb_org) 's Twitter Profile Photo

Heart disease affects 120M+ Americans, impacting daily life and family health. #Biotech teams are working on new treatments. If you save for retirement or pay insurance premiums, you may be helping. 🎥 Watch to learn more. #CommunityQuest #FixInsurance #ProtectInnovation

Genetics at BMC (@oagenetics) 's Twitter Profile Photo

Take a look at this recent Brief Report in Mobile DNA: Double-stranded DNA viruses may serve as vectors for horizontal transfer of intron-generating transposons. mobilednajournal.biomedcentral.com/articles/10.11…

Take a look at this recent Brief Report in Mobile DNA: Double-stranded DNA viruses may serve as vectors for horizontal transfer of intron-generating transposons.
mobilednajournal.biomedcentral.com/articles/10.11…
Ming "Tommy" Tang (@tangming2005) 's Twitter Profile Photo

1/ Many genomics mistakes are hard to catch in the code. They’re in the data you never looked at. Genome browsers can change that. Here’s how.

1/ Many genomics mistakes are hard to catch in the code.
 They’re in the data you never looked at.
 Genome browsers can change that. Here’s how.
Yuen San Chan (@chanyuensan) 's Twitter Profile Photo

Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…

Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7)
cell.com/molecular-cell…
Thomas Norman (@thenormanlab) 's Twitter Profile Photo

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Schübeler Lab (@schubelerlab) 's Twitter Profile Photo

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. sciencedirect.com/science/articl….

Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity.  sciencedirect.com/science/articl….
Scribe Therapeutics (@scribetx) 's Twitter Profile Photo

📣 New publication alert! Scribe and UC Berkeley scientists (Zachary Miller, Lokesh Narsineni et al.) have a paper out in the Journal of Controlled Release on a powerful new method for molecular characterization of lipid nanoparticles and mRNA packaging. Learn more below ⬇️

📣 New publication alert! Scribe and <a href="/UCBerkeley/">UC Berkeley</a> scientists (Zachary Miller, <a href="/narsinenilokesh/">Lokesh Narsineni</a> et al.) have a paper out in the Journal of Controlled Release on a powerful new method for molecular characterization of lipid nanoparticles and mRNA packaging.

Learn more below ⬇️
Scribe Therapeutics (@scribetx) 's Twitter Profile Photo

Deep learning for #CRISPR? We're presenting "DeepXE" at Cold Spring Harbor Laboratory's Genome Engineering: CRISPR Frontiers meeting—the 1st predictive model for on-target activity of our genome editor engineered from CasX. Learn how we're tapping #AI to design efficient gRNAs for therapeutics. #CSHL

Deep learning for #CRISPR?

We're presenting "DeepXE" at <a href="/CSHL/">Cold Spring Harbor Laboratory</a>'s Genome Engineering: CRISPR Frontiers meeting—the 1st predictive model for on-target activity of our genome editor engineered from CasX.

Learn how we're tapping #AI to design efficient gRNAs for therapeutics. #CSHL
Yodai Takei (@yodai_takei) 's Twitter Profile Photo

I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. biorxiv.org/content/10.110…

I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells.
biorxiv.org/content/10.110…
Lewis Lab (@peterlewislab) 's Twitter Profile Photo

PRC2 silences genes by adding H3K27me3 at the right spots in the genome. Our new work shows how the nucleic acid-binding domain (NBD) of SUZ12 keeps this activity under control, and what happens when you remove it.

PRC2 silences genes by adding H3K27me3 at the right spots in the genome. Our new work shows how the nucleic acid-binding domain (NBD) of SUZ12 keeps this activity under control, and what happens when you remove it.
Ming "Tommy" Tang (@tangming2005) 's Twitter Profile Photo

6/ Your fancy algorithm? Users care less than you think. They want to know: Will it solve my problem? How do I run it? How long will it take?

Prof. Nikolai Slavov (@slavov_n) 's Twitter Profile Photo

An elegant model: - TF binding events on nucleosome-free DNA are independent. - Yet, the activation domains of TFs recruit cofactors that destabilize nucleosomes, resulting in cooperative TF binding. - Average TF occupancy linearly determines promoter activity

An elegant model:

- TF binding events on nucleosome-free DNA are independent.

- Yet, the activation domains of TFs recruit cofactors that destabilize nucleosomes, resulting in cooperative TF binding. 

- Average TF occupancy linearly determines promoter activity
Scribe Therapeutics (@scribetx) 's Twitter Profile Photo

We’re proud to call Alameda our home and share with the San Francisco Business Times the history of our space (all the way back to WWI and WWII) and ability to invest in world-class talent to help us engineer the future of medicine. Read about our #biotech community: bizjournals.com/sanfrancisco/n…

Eric Joyce (@ericjoycelab) 's Twitter Profile Photo

🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. biorxiv.org/content/10.110…