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Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans rupress.org/jem/article-ab…

Wonderful inaugural GRC "Biology of Mycobacteria" meeting. Postdocs Hemant and Caldwell presenting their data. Looking forward to the next one in 2027!

Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source. biorxiv.org/content/10.110…

WHO announces landmark changes in treatment of drug-resistant #tuberculosis createsend.com/t/d-0CC16B595B…

In today's episode of the Night Science Podcast we talk with Martin Schwartz from Yale University about the importance of stupidity in science: while learning science makes you feel smart, true scientific discovery often involves feeling stupid, because it means venturing into the unknown.

Simultaneous measurements of translation rate and transcriptome in single bacterial cells by scTR-seq uncovers linked regulation ... biorxiv.org/content/10.110… #biorxiv_micrbio

Antigen avidity drives the durability of the vaccine immune response biorxiv.org/content/10.110…

Happy to share our Annual Reviews in collaboration with Musa Mhlanga Radboud University discussing Cellular and Molecular Mechanisms of Innate Memory Responses and raising more questions than answers! doi.org/10.1146/annure…

Check out our latest preprint, led by Siyu Chen, that brings together an amazing team of scientists from several labs to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? biorxiv.org/content/10.110…

Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins | Science science.org/doi/10.1126/sc…

Evolution of Mycobacterium tuberculosis transcription regulation is associated with increased transmission and drug resistance biorxiv.org/content/10.110… #biorxiv_micrbio

Farewell old lab space and welcome new! Thanks to all lab colleagues for making the move relatively smooth. Now fingers crossed all the equipment made it unscathed and we can get back to work in a few days!

New publication. We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With Benedetta Bolognesi Centre for Genomic Regulation (CRG) Wellcome Sanger Institute IBEC science.org/doi/10.1126/sc…

Next-generation rifamycins for the treatment of mycobacterial infections | PNAS pnas.org/doi/10.1073/pn…

I went on WBUR today to talk about the grant terminations and the importance of basic medical research wbur.org/news/2025/05/1…

Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonic… pubmed.ncbi.nlm.nih.gov/40354525/

Online today in nature - our latest study led by superstar postdoc Gilles Rademaker detailing the role of PSCK9 in driving sterol dependent metastatic organ choice in pancreatic cancer nature.com/articles/s4158… full text available here 👉 rdcu.be/em0VG and thread 👇

Was such a pleasure to have contributed to this episode that was initially aired a year ago or so and just went out as an updated version. My take on "adaptive mistranslation" and how "errors in the right context and degree...can make it more resilient.."

Targeting malaria parasites within mosquitos through topical drugs. In vivo screen of Plasmodium targets for mosquito-based malaria control nature.com/articles/s4158…

Very cool study on forward genetics of Mtb in the context of immunization. TnSeq identifies genetic requirements of Mycobacterium tuberculosis for survival under vaccine-induced immunity rdcu.be/enT0l