Olivier Delaneau 🧬 Introducing our latest release: Curated pipelines for genotype imputation using the 200k UK Biobank reference panel. Now, you can effortlessly impute SNP array & low-coverage WGS data! Check it out! srubinacci.gitbook.io/uk-biobank-imp…

Very pleased our manuscript is out today at Cell on the influence of autozygosity on common disease risk: doi.org/10.1016/j.cell… Thank you to the thoughtful reviewers that helped us improve our work! Check out the thread below for a summary of the main results

Hi #ASHG2023 ! 👋 Interested in the UK Biobank phased data I presented yesterday? Accessible to approved UKB researchers via #dnanexus. --> Meet Olivier Delaneau at poster 4261 today at 2:15 to delve into the application of these haplotypes for genotype imputation!

We have a new preprint out! This work shows the protective effects of LoFs in MAP3K15 in Type II diabetes risk (even on high risk PRS backgrounds), and importantly the "genetics driven recruitment" capabilities of the 23andMe database. medrxiv.org/content/10.110…

Great news! You can now browse the #500KGenomes summary statistics for all UK Biobank participants free of charge using our Allele Frequency Browser. The browser was launched on behalf of the Whole Genome Sequencing consortium. 🧬afb.ukbiobank.ac.uk

Oops! Samtools 1.19.1 had a bug which broke filtering on unordered BED files. This is now fixed in release 1.19.2. See htslib.org/download/ for links to tarballs and release notes.

We have three positions open in the Tree of Life Assembly team Wellcome Sanger Institute @SangerToL working on biodiversity genome assembly for Darwin Tree of Life, European Reference Genome Atlas, Vertebrate Genomes Project (VGP), Earth BioGenome Project 🌍.

23andMe is hiring a Senior Bioinformatics Scientist! Please apply, or share with those that may be interested! Feel free to DM me for more details. 23andme.com/careers/jobs/7…

A blog post on "Where did BWA came from?": lh3.github.io/2024/04/12/whe…

23andMe Research Amy Williams And our preprint is live! A great collab w Amy Williams and 23andMe Research, led by my amazing grad student Cole Williams ! “Phasing millions of samples achieves near perfect accuracy, enabling parent-of-origin classification of variants.” bioRxiv doi: biorxiv.org/content/10.110…

Not sure what's the causal gene at your favorite GWAS locus? Ask ChatGPT :) Interesting preprint on the value of LLMs in causal gene prediction by 23andme scientists (Suyash Shringarpure et al.) "Here, we demonstrate that large language models (LLMs) can accurately identify genes likely

The Hinch lab is looking for an enthusiastic statistician, mathematician or physicist to join us as a postdoc! If you'd like to use big data to decode the inner workings of our cells, apply now: germlinegenomics.web.ox.ac.uk Please RT! #PhDjobs #Postdocs #STEM #meiosis #genomics

Previous papers have shown that drug targets with supporting genetic evidence can have twice the success rate when reaching clinical trials. In our most recent paper (medrxiv.org/content/10.110…), we looked at how data from 23andMe can provide additional genetic evidence. 🧵1/8

Only 3 weeks left to apply! We're looking for computer scientists and statisticians to join our lab in solving cool and important biological puzzles. Check out: germlinegenomics.web.ox.ac.uk/node/3536851/

Excited to share our new work on the common and rare variant genetic architecture of cognitive ability across childhood and adolescence, using data from Children of the 90s, UCL Centre for Longitudinal Studies, and UK Biobank. medrxiv.org/content/10.110…

Very proud to be part of this study led by Anna Malaspinas, published in nature, exploring the genomic history of Rapa Nui. Huge shoutout to Barbara and Victor for their amazing work! Check out our findings here: nature.com/articles/s4158…

Thrilled to be in Denver with 14 colleagues from AstraZeneca’s Centre for Genomics Research, ready for 5 days of human genomics #ASHG24 The perfect chance to learn about how genomics is transforming drug discovery! Here’s a thread of our presentations - see you there 😀

🚨 Our preprint on parent-of-origin effects (POEs) is out! With our new method, we inferred the parental origin of >220,000 individuals, revealing new insights into the genetic architecture of complex traits. 👉 Read here: medrxiv.org/content/10.110… 👇 Highlights below!

Thrilled to receive the Early Career Award for my presentation at #ESHG2025! 🧬 Big thanks to all the amazing collaborators on this project — couldn't have done it without you. Grateful to the organizers and inspired by the science shared this week!

🚨 Our parent-of-origin study is out in nature ! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗nature.com/articles/s4158… Highlights below!