Is this the start of the resolution revolution in AFM? #journalclub doi.org/10.1038/s41586…

EMBL and @DeepMind have partnered – a breakthrough for science. Together, we're providing a treasure trove of protein structure predictions powered by #AlphaFold to herald a new era for #AI-enabled biology. embl.org/news/science/a…

Today in #journalclub: Structural Maintenance Complexes (SMCs) compact the DNA by extruding loops but what happens when multiple SMCs collide? nature.com/articles/s4159…

AlphaFold2 transmembrane protein structure prediction shines biorxiv.org/cgi/content/sh…

Membrane Constriction by ESCRT-III Proteins Induces Structural Lipid Bilayer Asymmetries biorxiv.org/cgi/content/sh…

A method for intuitively extracting macromolecular dynamics from structural disorder nature.com/articles/s4146…

Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites dlvr.it/SDhXz3

Excited to share new preprint from my lab Max Planck Institute of Biophysics in collaboration with #CamillaBjörkegren’s lab at Karolinska Institute! biorxiv.org/cgi/content/sh… (0/n) In this work, we reveal that Smc5/6 complex is a DNA loop extruding motor.

My postdoctoral work in #CDlab is finally out NatureStructMolBiol! In this work, we used single-molecule imaging to study how condensin navigates the under- and overwound DNA states (DNA supercoiling) abundant throughout the genome (1/3). 👇👇👇

Our new cryo-EM structure explains how the MRN complex can act both as DNA double-strand break sensor & DNA tethering device, read the paper here: authors.elsevier.com/c/1gK103vVUPK9… Huge thanks to all collaboration partners W.Roos, B.Steigenberger and C. Junge! #cryoEM, #DNArepair, #MRN

(1/n) The first paper from Eugene Kim lab is now online in nature! nature.com/articles/s4158… Using single-molecule imaging, we reveal that Smc5/6 is a DNA loop-extruding motor. Upon ATP hydrolysis, single Smc5/6 translocates along DNA, while dimerized Smc5/6 extrude DNA loops.

Thank you to Kristian, Camilla and Eugene's group for your hard work. Fingers crossed 🤞 biorxiv.org/content/10.110…

(1/2) Our collaborative work with Camilla's group on revealing Smc5/6's role in genome organization is now available in BioRxiv: biorxiv.org/content/10.110…

My latest PhD paper is now online Molecular Therapy! Huge thanks to the team efforts Dazzi Lab. A new mechanism for apoptotic #MSCs to deliver #immunosuppression. Such allows the identification of #CrohnsDisease patient who respond to MSC therapy. #ApoMSC dlvr.it/Sx6spf

Online Now: Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils dlvr.it/T25M82

(1/8) I am thrilled to share the latest work from @BisLightyear Amar Deep from Kevin Corbett Eugene Kim lab! biorxiv.org/content/10.110… We show that the bacterial SMC Wadjet complex cleaves plasmid DNA through loop extrusion.

Excited to see our Molecular Cell cover illustrating dimers of Smc5/6 recognizing transcription-induced positive supercoiling! Made by Camilla Björkegren.

Symmetry of loop extrusion by dimeric SMC complexes is DNA-tension-dependent biorxiv.org/cgi/content/sh… #biorxiv_biophys

Happy to share our recent work on symmetry of loop extrusion by SMC complexes! The work from @BisLightyear @Ekimlab biorxiv.org/content/10.110…

Our work on SMC Wadjet complex is finally out Molecular Cell ! Congrats to @BisLightyear Amar Deep Kevin Corbett & co.!