Great review paper! Figs 1-3 are collectively the most cogent explanation of ionizable lipid structure & function I have seen.

Who needs TikTok dance videos, when Science Twitter has far better moves? Bella Poarch is creative, but can she wiggle & penetrate cell membranes like DJ CPP? Amazingly cool work, & very instructive for the worlds of #nanomedicine, #nanotechnology, & targeted drug delivery.

Ton of fun moderating a session w V Muzykantov, MulderLab, Jamie Spangler at IMES, hosted by Kara L Spiller. #nanomedicine hit only base-hits & strikeouts for 40 yrs, but hit a grand slam by partnering w immunology. Lessons from this & the other success, mRNA-LNPs?

Cool use of RBC-hitchhiking (RH) to treat #ARDS (lung inflammation that kills in #COVID19), which is my favorite disease (yes, all docs have fav diseases to battle 🥷🔫⚔️). Smart to use positively charged #nanoparticles to help adsorb onto RBCs. Just watch out for complement.

Cute! Our lab makes #nanomedicine onesies for all our colleague-babies born into the #nanomedicine family! We've made for Kara L Spiller, The Drew Weissman Lab, & we're branching into puppies (sorry, kittens). Get one for a colleague (I mean their baby, we don't condone adult onesies 🤪)

Excited the full version of our Advanced Materials paper just published! Factor I conjugation to #nanoparticles blocks complement activation, prolonging NP half-life, improving organ- & cell-targeting, & preventing CARPA. & super EASY! onlinelibrary.wiley.com/doi/10.1002/ad…

Psyched about paper with close friend & colleague Hamideh Parhiz and The Drew Weissman Lab: Lipid #nanoparticles (LNPs) saved the world as #COVID19 vaccines & hold great promise. But when host has pre-existing inflammation at site of delivery, LNPs worsen it 10x! pubmed.ncbi.nlm.nih.gov/34953981/

Anti-vaxxers: This does NOT indicate danger of #COVID19 #vaccines. Vaccines go into your shoulder muscle, where there is no pre-existing inflammation. Our paper focuses on a risk for FUTURE applications of LNPs to express proteins to fix ARDS, sepsis, etc. #VaccinesSaveLives

As an ICU doc, I've cared for 100s of #COVID19 patients. Currently, many have TWO Viruses: #SARS-CoV2, AND a Mental Virus of false beliefs that vaccines + science = evil. We must show compassion for anti-vaxxers, as their mental virus was created in a lab: #FoxNews.

Check out our latest on the cover of today’s issue of Nano Letters led by Maggie Billingsley, PhD in collaboration w Carl June’s lab on orthogonal DOE methodology to create new mRNA lipid nanoparticles for engineering CAR T cells for cancer immunotherapy! Link: pubs.acs.org/doi/10.1021/ac…

Wow, we in #nanomedicine have so much to learn from nature, and our colleagues studying exosomes / extracellular vesicles. Great leadership by Hamid Ghandehari & Editors of Advanced Drug Delivery Reviews to put work like this in ADDR.

Nanomedicine Kung-Fu! 🥷 Our Advanced Materials (@AdvSciNews) paper from yesterday is featured in Penn Medicine News, showing conjugated Factor I can act like a Kung-Fu Master to protect #nanoparticles & gene therapy from complement. #nanomedicine #GeneTherapy pennmedicine.org/news/news-rele…

New Research: Nanoparticle-Induced Augmentation of Neutrophils’ Phagocytosis of Bacteria frontiersin.org/articles/10.33… #pharmacology

Can resilience be learned? A new study from Princeton University researchers finds that prior stressful events can help build resilience. Princeton Neuroscience Institute research.princeton.edu/news/can-resil… or see the article nature nature.com/articles/s4158…