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Most mitochondrial health research focuses on biogenesis—the creation of new mitochondria. But a new wave of evidence is revealing something more fundamental: it's not how many mitochondria you build—it's how efficiently you clear the damaged ones. We synthesized findings from

Protein alımıyla ilgili en son bilimsel derleme: -Yaşlılar ve sporcularda 1.2–1.6+ g/kg protein alımı kas korunumu için daha faydalı -Sağlıklı kişilerde yüksek proteinin böbreklere zarar verdiğine dair kanıt yok -"Protein en tok tutan besindir" inanışının bilimsel desteği zayıf

Metformin’s Real Target May Be the Gut Mitochondrion, Not the Liver For decades, metformin has been explained mainly as a liver drug: suppress hepatic gluconeogenesis, lower fasting glucose, activate AMPK, improve insulin sensitivity. A new Nature Metabolism paper reframes that

Mitochondrial stress and aging: Lessons from C. elegans sciencedirect.com/science/articl…

Same food, different metabolic response – because of your genes, epigenetics, and gut microbiome. Universal diets don't work. Before jumping to another fad diet: check APOE, TCF7L2, and your microbiota. For now: fiber, less sugar, regular meals. sciencedirect.com/science/articl…

Your coffee may literally be keeping you young. Research shows it activates the same cellular pathways targeted by anti-aging drugs. That morning cup of joe is doing far more than just shaking off the sleep. New research from Queen Mary University of London reveals that

Most coffee research asks whether it prevents cancer. This study asked something different: among people who already have colorectal cancer, does coffee affect how long they live? Kim and colleagues pooled 4 prospective cohort studies covering 5,442 colorectal cancer patients.

New YT video, featuring George J. Murphy! youtube.com/watch?v=WJfG87…

A new study just reversed aging by 73% in old, near-dying bodies. Researchers found a way to silence the toxic signals in your blood that force your body to age. I'd bet my life savings you'll be shocked after reading this thread:

Metformin's primary action may be in the gut, not the liver. New Nature Metabolism paper found intestinal concentrations hit 10-100x liver levels, the only tissue where the drug reaches the mM range needed to inhibit mitochondrial Complex I. Mice engineered to resist Complex I

Lancet Araştırmasına göre: Günde 7000 adım yürümek, günde 2000 adım yürümeye kıyasla: - Tüm nedenlere bağlı ölüm oranında %47 azalma - Kalp damar hastalıklarına bağlı ölüm oranında %47 azalma - Kansere bağlı ölüm oranında %37 azalma - Demans riskinde %38 azalma - Depresyon

Dikkat! Yakında gençlik aşısı gelebilir 🤲 Korea Üniversitesi araştırmacılarının 2025 yılında Metabolism dergisinde yayımladığı çalışmada, yaşlanan hücrelerin salgıladığı ReHMGB1 (redoks duyarlı HMGB1 proteini) adlı bir proteinin, kan yoluyla vücuda yayılarak sağlıklı dokularda

Why is there such obsession with extending lifespan when the bigger issue is that average healthspan is 65 years and there are no data (except in super-centenarians) that longer lifespan = longer healthspan (known as compression of morbidity)?

Waist size determines insulin sensitivity, not age. Since insulin sensitivity is strongly related to protection from virtually all chronic disease, such as heart disease, cancer, and diabetes the best way to prevent those diseases is to get lean, fit, and strong.

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults onlinelibrary.wiley.com/doi/full/10.11…

Las cataratas son la principal causa de ceguera en el mundo y afectan a decenas de millones de personas. Actualmente, la única solución médica establecida para recuperar la visión implica someterse a una intervención quirúrgica. Sin embargo, investigadores encontraron una

Interesting! The Psoas muscle is one of the most important muscles, holding our upper & lower halves together. Yet, 1 in 2 people lacks a Psoas minor Whether you have one or not, get a standing desk! It will strengthen your Psoas major, giving you better stability at any age