Happy Friday everyone! Our new pre-print is out! In it we explore how the genetic aetiology varies through systematic addition of components in a diagnosis of major depressive disorder (impairment, duration etc.). Welcome any thoughts! medrxiv.org/content/10.110…

PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics cell.com/ajhg/fulltext/…

Faculty of Health @RealHealthM - Brittany Mitchell Exploring the genetic relationship between hearing impairment and Alzheimer’s disease. eprints.qut.edu.au/206652/ #BrittanyMitchell

A systematic analysis of genetically regulated differences in gene expression and the role of co-expression networks across 16 psychiatric disorders and substance use phenotypes biorxiv.org/cgi/content/sh… #bioRxiv

Many psychiatric disorders and substance use outcomes share genetic effects. Controlling for genes associated with socio-economic outcomes changes the genetic relationships between these mental health outcomes. Our paper just out in Nature Human Behaviour 🧬💸🧠 nature.com/articles/s4156…

Exciting new work by Gaby Lunansky et al. on #network #resilience. frontiersin.org/articles/10.33…

Our paper modelling symptoms of anxiety, depression and neuroticism is now out in Nature Human Behaviour Link to paper: rdcu.be/ciK6a Big thanks to Eske Derks Adrian C. @zac_gerring @QIMRBerghofer

Excited about my new preprint where we looked at genetic evidence of correlation and potential causal relationships between a panel of ~ 50 blood based biochemical markers and 10 psychiatric traits. Murray Cairns Melissa Green Hunter Medical Research Institute (HMRI) University of Newcastle. Short tweetorial 1/13

Our preprint exploring sociodemographic and genetic factors linked to optional prescription record linkage in the AGDS is out! Thanks to everyone involved in this important study!

Very proud of this piece of work where we look at the aetiology of antidepressant side effects in a large sample: nature.com/articles/s4385…

In a slight shift in focus, our most recent study, published today in Nature Communications, was a large GWAS meta-analysis of acne. Using data from 9 research centers around the globe we were able to identify 46 variants associated with acne risk (29 novel).

Our article summarising some of the key challenges for the field of psychiatric genetics is out now in Nature Genetics. As always, an absolute pleasure to write this with Eske Derks and @zac_gerring @QIMRBerghofer nature.com/articles/s4158…

Today, our paper on attrition and selection using data from the Australian Genetics of Depression study was published. (1/8) doi.org/10.1007/s00406…

The last of my PhD papers is now published! We looked at the association between depression PRS, trauma exposure, their interaction, and individual depression symptoms Psychiatry Research Journal Big thanks to Eske Derks @zac_gerring and all co-authors authors.elsevier.com/a/1gZoDbZg7M9hb

Ever wondered how many symptoms make up all of adult psychopathology described in the DSM-5? It’s 628! How many do you think repeat across multiple diagnoses? If you answered 231 symptoms repeating a total of 1022 times (median 3 times per symptom, range 2-22), good job! 🧵

Our new paper identifying drug repurposing candidates for anxiety is out now! authors.elsevier.com/c/1hRPHbZg7MAGv Big congrats to Damian Woodward for his first publication. Many more great papers to come.

An exciting study by Burstein et al. investigated the genetics of binge eating disorder. We discuss the main findings of their work nature.com/articles/s4158… @zac_gerring Jackson Thorp @QIMRBerghofer Nature Genetics

We are hiring postdocs! Join the Eske Derks lab in warm and sunny Brisbane! Get in touch if you are interested in 1) multivariate genetic modelling of psychiatric/related traits; and/or 2) functional interpretation of GWAS loci/drug repurposing. More info seek.com.au/job/75121783?r…

Our review of the genetics of substance use disorders is out now in molecularpsychiatry @zac_gerring, Eske Derks, Jorien Treur, Karin Verweij nature.com/articles/s4138…

You've heard of DNA, but what about GNA? New preprint from Jackson Thorp and IBG member Andrew Grotzinger that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics medrxiv.org/content/10.110…