Tomorrow!

And thank you to the best PhD mentor in the game, @timothyjhohman!

Why did we need to update the human genome reference sequence? When it was created during the Human Genome Project, around 70% of it came from only one person with blended ancestry, which includes African, European, Admixed American, East Asian and South Asian ancestry.

Tune in to NewsChannel 5 PLUS OpenLine TONIGHT at 7 p.m. CST as Angela Jefferson answers questions about #alzheimers disease + related #dementias. 🧠 Call 615-737-7587 (PLUS) with questions.

🙌 Dear all - join us this Friday, Feb 9, at 10 a.m. CT to know more about "Healthy Diets, Omics Pathways, and Cognition" 🥕Speaker Jun Li 🧬Moderator Puja Agarwal 🧠Registration alz-org.zoom.us/webinar/regist… ISTAART Alzheimer's Association Nutrition, Metabolism and Dementia PIA Ana Capuano Debora Melo van Lent

Happy World Caring Day! Let's spread kindness and compassion far and wide. Remember, caring is contagious! #WorldCaringDay #SpreadKindness

New out in Nature!! With age, women can lose one X chromosome in their leukocytes. What’s the cause/consequence? How does it differ from the loss of the Y chromosome in men? nature.com/articles/s4158… Broad Institute FinnGen FIMM HelsinkiUni National Cancer Institute Cambridge University

We are thrilled to host our next speaker Dr. Kaitlin Casaletto Kaitlin Casaletto at the Ann S. Bowers WBHI Seminar Series next Monday, July 8th! 💜 🧠 We now have nearly 400 registrants from more than 30 countries, please register via shorturl.at/ikD27 if you have not already.

New review paper out now on sex differences in resilience to Alzheimer's disease. I'm grateful to have been a part of contributing to this great resource! Check out the paper below! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Check out this tour de force review on Sex Differences in Resilience in #Aging and #Alzheimers spearheaded by Eider Arenaza-Urquijo. Women show advantage in cognitive resilience and reserve in aging and this advantage diminishes in AD when they eventually show faster cognitive decline.

Check out our paper from the Harvard Aging Brain Study Brain Study where we identified older adults with cognitive resilience to amyloid, tau, and neurodegeneration who showed higher levels of verbal intelligence and past cognitive activity: doi.org/10.1186/s13195… Reserve, Resilience and Protective Factors PIA

Molecular characterization of well phenotyped #Alzheimers cohorts will identify biomarkers and casual and druggable targets. In the Knight ADRC cohort we generated genetics, epigenetics, transcriptomics, proteomics and metabolomics in brain, CSF and blood. nature.com/articles/s4159…

The figure we all have to learn by heart: The updated Lancet Commission on potentially modifiable risk factors for dementia. #AAIC24

🚨 New Study Alert out in Alzheimer's & Dementia Journals! In our latest publication, led by Guilherme Povala and #MarcoDeBastiani, we present a modular-oriented transcriptomic integration approach combined with neuroimaging to uncover novel insights into AD pathology👇🧶tinyurl.com/mv6bt835

Via JAMA Neurology: A study could lead to insights into how the sex of parents contributes to higher brain amyloid-beta burden and reduced brain metabolism: bit.ly/3yIzshc #NeuroTwitter Hyun-Sik Yang KU Alzheimer's Disease Research Center Liana Apostolova, MD, MSc, FAAN National Alzheimer's Coordinating Center (NACC) UW Medicine Pitt Neurology Wake Forest University School of Medicine

Exome-wide association study of 601 diseases in ~0.75 million individuals (UK Biobank, Mass General Brigham Biobank, All of Us) replicates many of the discoveries previously made in the UK Biobank (e.g. GIGYF1 - type 2 diabetes) and identifies new associations (e.g. YLPM1 -

🩸 Imagine diagnosing Alzheimer’s with just a drop of blood. Cutting-edge research suggests it could soon be that simple. Modern ultra-sensitive immunoassays are now capable of detecting key markers—like p-tau isoforms, GFAP, and NfL—in a single drop of blood. This breakthrough

For nearly 2 decades, Alzheimer’s disease (AD) “genome-wide” association studies only covered the autosomes. Today we unveil the X chromosome and prioritize SLC9A7, a.k.a. NHE7, as an AD risk gene. Article: jamanetwork.com/journals/jaman… Editorial: jamanetwork.com/journals/jaman…

This X chromosome-wide association study of Alzheimer disease (AD) across 1,152,284 individuals identified SLC9A7 as a novel risk locus and provides initial insights into the role of X chromosome in sex-based differences in AD. ja.ma/3XCfhLE

Interested in combining neuroimaging and multiomics in AD? Check out our new review on this topic, just published in Cell Reports Medicine. We focus on integration with amyloid- and tau-PET and all the challenges that come with it. w/ Niklas Mattsson-Carlgren cell.com/cell-reports-m…