In the ACHIEVE-1 phase 3 trial, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes. Full trial results and Research Summary: nej.md/4ngEZ36

In the PROMIZING trial, proportional-assist ventilation with load-adjustable gain factors did not differ significantly from pressure-support ventilation with respect to the time to liberation from mechanical ventilation. Full trial results and Research Summary:

Which is better? Lactated Ringer’s solution or normal saline? The latest video in our partnership with Dr. Glaucomflecken summarizes the FLUID trial. 👉 nej.md/DrG26

Among patients with venous thromboembolism who have a transient provoking factor and enduring risk factors, the appropriate duration of anticoagulation is uncertain. Research findings from the HI-PRO trial are summarized in a new Quick Take video. nej.md/48s6HVq

Vitamin D (2000 IU/day) reduced advanced cancer risk (metastatic or fatal) by 17% over 5 years The effect was most pronounced for those with BMI <25: advanced cancer was reduced by 38%

Presented at #KidneyWk: In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results:

In stable AKI patients, indication-based dialysis enabled faster liberation from dialysis and reduced health care resource use compared to conventional thrice-weekly treatment. 🧵 #KidneyWK American Society of Nephrology ja.ma/4qO10rI

For moderate-to-severe plaque psoriasis, biologic therapies are highly effective but are available only by injection, and current oral therapies are often less effective. Research findings from the ICONIC-LEAD phase 3 trial are summarized in a Quick Take video.

Meta-analysis: #SGLT2 inhibitors slow kidney decline consistently across CKD severity and albuminuria range, supporting their routine use for kidney health. 🧵 #KidneyWK American Society of Nephrology ja.ma/4oniolr

In intermediate-risk breast cancer, postmastectomy chest-wall irradiation did not improve 10-year overall survival as compared with no chest-wall irradiation. Full SUPREMO phase 3 trial results and Research Summary: nej.md/3Jxd3sI #MedSky #Oncology

Evolocumab in Patients without a Previous Myocardial Infarction or Stroke: NEJM AHA Science #AHA25 🥸VESALIUS-CV - subtilisin–kexin type 9 (PCSK9) inhibitor evolocumab 😱Summary 👇👇👇

Original Article: Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (PISCES trial) nej.md/49zWuqo Editorial: Fish Oil for Patients Receiving Hemodialysis — Red Herring or Great Catch? nej.md/49zWAOM American Society of Nephrology | #KidneyWk

Presented at #AHA25: In patients with atrial fibrillation and a drug-eluting stent placed at least 1 year earlier, monotherapy with a non–vitamin K antagonist oral anticoagulant was noninferior to combination therapy with clopidogrel for net adverse clinical events. Full ADAPT

Presented at #AHA25: In patients with atrial fibrillation after successful ablation, rivaroxaban therapy did not lead to a significantly lower incidence of a composite of stroke, systemic embolism, or new covert embolic stroke than aspirin therapy. Full OCEAN trial results:

A new review by Andrea Giustina, MD, and Annamaria Colao, MD, PhD, updates the pathophysiology and disease course of acromegaly, focusing on the general clinician’s key role in early diagnosis and management. At diagnosis, approximately 70% of patients with acromegaly have

Original Article: Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction (REBOOT trial) nej.md/45QYbws #Cardiology

People who are more optimistic tend to live longer In a study following a large cohort for decades, the most optimistic individuals had: 1) 11-15% longer life span 2) 1.5-1.7x greater odds of reaching age 85+

Aneurysm wall enhancement on MRI, particularly circumferential AWE, may be used to predict the risk of instability in unruptured intracranial aneurysms over a four-year period. ja.ma/49esWi9

Beta-blocker use after myocardial infarction reduces the risk of death in patients with a reduced ejection fraction, but its benefit is less clear in patients without a reduced ejection fraction. Research findings from the REBOOT trial are summarized in a new Quick Take video.

Bedside clinical skills have been diminished by an overreliance on technology. A new Review Article presents educational strategies for reinvigorating the bedside encounter and shows how much can be learned from it. Read the review “Strategies to Reinvigorate the Bedside