Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain: sciencedirect.com/science/articl…. I guess it's time to revise the "no pain, no gain" hypothesis

NEW: The world's leading protein design lab is at it again David Baker's lab newest publication in Science is on making enzymes from scratch with AI Future uses range from more precise gene-editing enzymes to proteases that hit more targets: endpts.com/david-baker-la…

Latigo is looking to raise more capital to advance its non-opioid pain treatment, joining Vertex in the race to develop safer pain drugs. endpts.com/pain-biotech-l…

A couple reflections on the quantum computing breakthrough we just announced... Most of us grew up learning there are three main types of matter that matter: solid, liquid, and gas. Today, that changed. After a nearly 20 year pursuit, we’ve created an entirely new state of

AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, Arc Institute in collaboration with NVIDIA releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life 🧵

🧬 Evo 2 isn’t just an AI model—it represents a foundational shift in how we understand and design life, bridging molecules, systems, and organisms. The next era of biology has arrived, and there is no shortcut to long-context models. #NVIDIAhealthcare #NVIDIANIM

Large epidemiologic studies have consistently shown an association between coffee and improved health outcomes. This may be one of the reasons: favorable changes to the gut microbiome ☕️☕️ scientificamerican.com/article/coffee…

How do you get to the nitty-gritty of Parkinson's disease? Do high-throughput proteomics. nature.com/articles/s4358…

The three stars in Orion compared to the Sun: The stars in Orion's Belt are simply massive. They are all blue supergiants: Alnitak, Alnilam, and Mintaka.

Our March issue is live! Read about muscle-growing drugs, chemical engineering of CRISPR-Cas systems, the therapeutic landscape for MASH, targeting metabolic dysfunction of CD8 T cells and NK cells in cancer and more here nature.com/nrd/volumes/24…

GDNF, a neurotrophic factor, reduces protein aggregation pathology in midbrain neurons despite the defective protein degradation. Final article from my PhD is published, open-access: sciencedirect.com/science/articl… Life Sciences University of Helsinki University of Helsinki MDS The Science of Parkinson's (1/7)

My personal take-ins from the study: 1) GDNF is a very potent molecule against protein aggregation in PD that should be applied with caution against overdose. 2) There is a need for more models with less acute protein degradation stress for mimicking neurodegeneration. (6/7)

Top companies and drugs by sales in 2024 tinyurl.com/yc22rzsh Merck & Co’s cancer immunotherapy Keytruda solidified its top place, and GLP-1 receptor agonists for diabetes and obesity are shaking up the rankings. Read more in this new analysis by Paul Verdin Evaluate Pharma

A paralysed man can stand on his own after receiving an injection of neural stem cells to treat his spinal cord injury go.nature.com/41ZCoRj

🧠 Janelia researchers have mapped out the step-by-step process of cognitive map formation in the brain’s hippocampus during learning and identified the type of mathematical model that best reproduces this learning process ➡️ janelia.org/news/mapmaking…

The Fourier Transform is a mathematical operation that transforms a function of time (or space) into a function of frequency. In essence, it decomposes a complex signal into its constituent sinusoidal components, each with a specific frequency, amplitude, and phase. This is

Introducing The Darwin Gödel Machine: AI that improves itself by rewriting its own code sakana.ai/dgm The Darwin Gödel Machine (DGM) is a self-improving agent that can modify its own code. Inspired by evolution, we maintain an expanding lineage of agent variants,

Introducing the world's first reasoning model in biology! 🧬 BioReason enables AI to reason about genomics like a biology expert. A thread 🧵:

A discovery of a gene underpinning the perception of pain with implications for treating the chronic condition that affects 600 million people globally economist.com/science-and-te… nature.com/articles/s4158…

This is a cool paper, but not sure if the findings are impressive enough to be too excited about. The authors used a GWAS of a pain phenotype and decided to study a gene (SLC45A4) at a specific locus in detail. The genetic association itself is robust, replicates across