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What a privilege to work with this group! 🥂

One superstar at our lab holiday party and his only scientific interest is optimizing cuddles, treats, and toys! #FahedLab MGH Cardiovascular Research Center Broad Institute

Milestone moment! #FahedLab launched its first lab meeting today. Proud to be part of a team dedicated to transforming cardiac health for generations to come 🫀 Akl Fahed MGH Cardiovascular Research Center Broad Institute Harvard Medical School

Most cardiovascular risk factors are continuous measures of exposure with a well-defined relative risk curve. Why are we obsessed with binarizing risk stratification? In this npj Journals paper, Yichi Zhang (张一弛) MGH IM Residents medical resident extraordinaire explores the concept of

Delighted to share our study led by Harvard University undergrad Akshaya Ravi with Broad Institute postdoc Satoshi Koyama describing a general inverse genetic relationship between LDL-C and incident T2D. jamanetwork.com/journals/jamac… JAMA Cardiology

Mini-Review Polygenic Risk Scores in Human Disease Dimitri Maamari, MD Roukoz A. Karam, MD

The relationship of high polygenic risk scores to coronary artery disease disease for extent of atherosclerosis and presentation with heart attack/unstable angina jamanetwork.com/journals/jaman… JAMA Network Open Akl Fahed Kelvin Supriami Pradeep Natarajan Patrick Ellinor

NEW in Circulation: Genomic and Precision Medicine led by Sarah Urbut Genomic and clinical risk factors of CAD display time-varying importance over the life course. The importance of CAD PRS is highest earlier in life and diminishes with older age. Collab with Pradeep Natarajan Mass General Heart MGH Cardiovascular Research Center

Delighted to share our study by Sarah Urbut with Akl Fahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events ahajournals.org/doi/10.1161/CI… Circulation: Genomic and Precision Medicine

Congrats to our very own Sarah Urbut, FIT representative of the AHA Science 2025 stats update! ahajournals.org/doi/10.1161/CI… Circulation MGH Cardiology Fellows Seth Martin

Learn about polygenic risk score research from the best - very fortunate to work with Yunfeng Ruan🌻 #StandWithUkraine🌻 in my group Broad Institute cc PRIMED Consortium BroadMPG AHA Council on Genomic and Precision Medicine

We're thrilled to share our latest publication, A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies, in Nature Computational Science. Sincerely thanks to Xihong Lin for incredible mentorship, Zilin Li, Zhonghua Liu, Pradeep Natarajan, Dr.

New preprint out on PennPRS: a centralized cloud computing platform for efficient polygenic risk score training in precision medicine Tian Ge Dr. Marylyn D. Ritchie, PhD Bogdan Pasaniuc Genevieve Wojcik, PhD MHS Website: pennprs.org Preprint: medrxiv.org/content/10.110…

Terrific work in Hypertension led by So Mi Jemma Cho demonstrating differential blood pressure trajectories among East and South Asian individuals living in the UK with resultant differing prognostic influences on CVD. See 🧵 by So Mi Jemma Cho 👇

Individual polygenic risk scores for the same trait can yield different results due to various derivation differences. Our study led by A. Misra & w Aniruddh Patel demonstrates how successive score integration can improve accuracy & stability nature.com/articles/s4146…

🧵1/ Last year, a thoughtful reply to our JAMA article sent me down a rabbit hole on CVD prevention. Should statins be prescribed less or more often? Available OTC? Added to the water supply?? Let’s talk trials, thresholds, and tradeoffs!

Five years of work, one big question: Which has a greater impact on aging—our environment or our genes? I'm excited to share our paper published today in Nature Medicine, demonstrating the major role of the #exposome in shaping mortality and #aging. nature.com/articles/s4159…

Tomorrow we welcome Pradeep Natarajan as an Associate Editor for cardiology. Dr Natarajan previously served as an Associate Editor at JAMA Cardiology and as an Associate Editor for Science Advances. He currently holds positions at both MassGeneral News and Harvard Medical School.

Very excited to join the JAMA team & contribute to the field of cardiology in this new way! As a reader, author, peer reviewer, and editor, I am deeply invested in the process of producing & communicating high-quality biomedical research. I will deeply miss regularly

Two new papers in Nature Genetics from Patrick Ellinor and team Expanding genetic discovery of rare, structural and common variation in atrial fibrillation Sequencing >50K cases nature.com/articles/s4158… GWAS >180K cases nature.com/articles/s4158…