🆕🔥Case-control study Brad Spellberg Just 1/4 blood cultures positive (≥2 sets drawn) or early clearance → low IE probability. Persistent bacteremia or 4/4 bottles ↑ pretest probability. Simple bedside clues to sharpen your endocarditis game. #IDXposts jamanetwork.com/journals/jaman…

🆕💫The MEFIER Score - A Risk Score to Stratify Infective Endocarditis in Patients with Enterococcus faecalis bacteremia based on an 11-year territory-wide cohort AUROC of 0.79 (95%CI 0.72-0.88), and a NPV of 0.98 (95%CI 0.97-0.99) #idxposts #IEWiki academic.oup.com/ofid/advance-a…

🆕💫Navigating troubled waters: a systematic review of prosthetic valve endocarditis reported cases treated with suppressive antimicrobial treatment #idxposts #IEWiki ijidonline.com/article/S1201-…

N=466 på 2 år og 30 dages mortalitet på 52% 💀 Fokus på antimicrobial stewardship 🦠 så vi undgår et lignende scenarie i Danmark 🇩🇰

🆕🌟Excellent podcast A debate on antibiotic choices and the controversy between bactericidal and bacteriostatic antibiotics Brad Spellberg Cesar Arias #IDXposts asm.org/podcasts/edito…

🔺NEW - Treatment and Follow-up of Vascular Graft and Endograft Infection: Delphi Consensus Document (2025)

🆕💫LTE Impact of Extending Beta-Lactam Infusions on IV Access Requirements BLOOM study #IDXposts journals.lww.com/ccejournal/ful…

🆕🔥 Review article The Lancet Infectious Diseases Towards shorter therapy for candidaemia: defining uncomplicated candidaemia in adults #IDXposts thelancet.com/journals/lanin…

🆕🔥Streptococcal endocarditis: a meta-analysis of species dependant risk 🌟Updated figure 🌟Infective endocarditis prevalence of streptococcal species vs. proportion of streptococcal species bacteraemia #IEWiki sciencedirect.com/science/articl…

Should we extend the use of oral antibiotics in infective endocarditis? The ENDO-ORAL study bit.ly/45GkXXs

Linezolid-related Optic Nerve Disorders: Insight from a Pharmacovigilance Analysis of the U.S. FDA Adverse Event Reporting System ✅ Just Accepted bit.ly/45V2zum

🆕🔥State of art review with 🌟s J-Francois Timsit Jason Roberts Antibiotic therapy for severe bacterial infections 🟢When to start and not to start antibiotics? 🟢Mon vs combo Abx 🟢PK/PD principles 🟢Drug–drug inx A #mustread article for ID professional link.springer.com/article/10.100…

🆕💫Antibiotic treatment duration for isolated MSSA native tricuspid valve endocarditis: a standardized multidisciplinary approach( including a CVS ID consult service and multidisciplinary team) #IDXposts #IEWiki Brad Spellberg Todd C. Lee Emily McDonald academic.oup.com/jacamr/article…

What the DOTS trial of Staph bacteremia tells us: • Dalbavancin d1 and d8 vs daily IVs for WEEKS • No left-sided IE/CNS/prosthetics • Dalba not superior by DOOR endpoint, but similar clinical outcomes. Big implications for inpt care. More in link ⬇️⬇️⬇️

For those who are interested or who missed it, here's the link: youtu.be/EOD4igxbFbg?si… Comments and engagement welcome Particularly excited about Emily McDonald 's dabi-snap trial getting started soon

🆕💫 Retrospective study Efficacy, safety, and population pharmacokinetics of a single 1500mg dose of dalbavancin as a sequencing treatment* in patients with Gram-positive** chronic prosthetic joint infections #IDXposts #OMWiki journals.asm.org/doi/10.1128/aa…

🆕💫Dual β-lactam synergy in Enterococcus faecalis and its relationship with penicillin-ceftriaxone infective endocarditis treatment outcomes #IDXposts #IEWiki academic.oup.com/jac/article/do…

🆕🔥🔥CloCeBa RCT Cloxacillin versus cefazolin for MSSA Bacteraemia Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDXposts Thanks Ignacio uman thelancet.com/journals/lance…

Fungal endocarditis (FE), a rare but severe subset of infective endocarditis (IE), accounts for 2–4% of cases, with significant morbidity and mortality despite combined clinical and surgical interventions #IEWiki #IDXposts

🆕💫Nationwide study, in patients with E. faecalis BSI, the six months incidence of colorectal cancer and colorectal neoplasia was low (approximately 0.5% and 2.3%, respectively #IDXposts journalofinfection.com/article/S0163-…