Oncogenic context shapes the fitness landscape of tumor suppression biorxiv.org/cgi/content/sh… #bioRxiv

Woo! So proud of my D2G family, amazing to have this pre-print out on bioRxiv. Huge thanks to Lily Blair and the rest of our phenomenal team and collaborators for getting this across the finish line! A big step forward in our understanding of genetic interactions in lung cancer.

Very proud of this work! I am going to write a longer thread but for now, check out the paper (biorxiv.org/content/10.110…) and the thread below. The fitness landscape of tumor suppression is complex and cannot be gleaned from simple linear idea of EGFR->KRAS->BRAF signaling 1/n