Now published in Peer Community Journal, #genomics section: A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice, Wiki and Databases doi.org/10.24072/pcjou…

Spacedust: de novo discovery of conserved gene clusters. Combining sensitive Foldseek structure search and conserved neighborhood detection to discover functionally-associated gene clusters in prokaryotic & viral genomes. 🚀github.com/soedinglab/spa… 📄biorxiv.org/content/10.110… 1/6🧵

Two years ago we published the discovery of hotspots of novel anti-phage defense systems in the genome of P4 phage satellites, including a mysterious Phage Anti-Restriction Induced System (PARIS). We have now published the mechanism in nature nature.com/articles/s4158…

🔥New paper out in Science!!🔥 Science Magazine We found that a third of the seed dispersers and interactions face potential extinction, in Europe 🌿🌳🐦‍⬛🦆🌍 This was an incredibly challenging (and rewarding!) chapter of my PhD thesis! #seeddispersal science.org/doi/abs/10.112…

Why do #bacterial species' #TransformationRates vary so dramatically? @epcrocha @labXC &co show that #Legionella & #Acinetobacter transformation rates evolve by sudden changes, likely caused by conflicts between #MGEs and the host bacterium #PLOSBiology plos.io/4dMviTR

"La biodiversité ne s'effondre pas en Europe". Ce titre du Point vous aura, au choix, hérissé le poil, fait sourire ou acquiescer. Un discours à contre-courant, mais avec quels fondements? Je tente de le mettre en perspective avec mon oeil d'écologue et un peu de science 👇🏻 1/n

#Plants use NLRs for #pathogen defense, but what do downstream "helper" #NLRs do? M. Selvaraj Mauricio Contreras Sophien Kamoun &co reveal that the helper NLR NRC2 flips from autoinhibited homodimer to active oligomeric resistosome upon activation #PLOSBiology plos.io/40e5fBU

Plus d’une espèce d’arbre sur trois est menacée d’extinction à travers le monde lemonde.fr/planete/articl…

OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information, by Aude Bernheim Hugo Vaysset MDMLab @iame_center Bacteriophage Lab Institut Pasteur nature.com/articles/s4156…

TED: The Encyclopedia of Domains now published in Science Magazine discovering and annotating 314 MILLION protein domains in the AlphaFold database. joint work of @CATH_Gene3D and PSIPRED here at UCL.

Out Nature Microbiology, we predicted phage-bacteria interactions in E. coli species using only genomic information. Adsorption, not defense systems, is the main driver at this scale (relevant for a phage therapy context), leading to tailored cocktails! nature.com/articles/s4156… 🧵👇

Amyloid signaling in antiphage defense biorxiv.org/cgi/content/sh… #biorxiv_micrbio

9th French Phage Network meeting next week in Sète! See program here: site.phages.fr/explorer-resso…

Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2

For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species. We are thrilled to see this work now published in Nature Microbiology after thorough peer review! nature.com/articles/s4156…

🌟👏 Félicitations à Aude Bernheim Aude Bernheim, lauréate du Prix Irène Joliot-Curie dans la catégorie « Jeune femme scientifique » pour ses travaux sur l'immunité bactérienne et son rôle dans la défense antivirale et l'immunité humaine.

OUT NOW: Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons Sternberg Lab MDMLab Hugo Vaysset nature.com/articles/s4156…

Protein and genomic language models chart a vast landscape of antiphage defenses biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Excited to share our work using machine learning to predict anti-phage defense systems! 1/n