🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

What to do when there are just too many mutants to be characterised - Stefanie Neun, Liisa Van Vliet & collab Fabrice Gielen bring droplets to the rescue: HT Steady-State Enzyme Kinetics Measured in a Parallel Droplet Generation and Absorbance Detection Platform pubs.acs.org/doi/full/10.10…

Esther Richter et al. integrate acoustic sorting with absorbance detection for more rapid ultrahigh throughput droplet screening. Great collaboration led by Thomas Franke’s group in Glasgow EVOdrops_ITN pubs.rsc.org/en/content/art…

Stefanie Neun at al demonstrate (in collab with markohyvonen bsky social) how droplet microfluidics can identify functions in metagenomic libraries that were not predicted by sequence-based methods. The quest for correct, comprehensive annotation starts here ... nature.com/articles/s4158…

By evolving a promiscuous hydrolase recruited from a metagenomic library David Schnettler et al. show how a catalytic triad, more familiar from esterases and proteases, can also enable efficient phosphate triester hydrolyis. pubs.acs.org/doi/10.1021/ja…

Looking forward to interacting and collaborating with the BlueRemediomics initiative! ebi.ac.uk/about/news/ann…

Happy to see our paper from Hollfelder Lab out in Nature Communications. In this work we describe a #DirectedEvolution method for proteases based on protease inhibitors called alpha-2-macroglobulins (A2Ms). nature.com/articles/s4146…

Who are we? Bluetools brings together five top European companies, eight university teams, and one private training organisations to pioneer methodologies in functional metagenomics, microfluidics, microbial ecology, and synthetic biology. Learn more: fal.cn/3z2my

SanntiS uses machine learning to identify biosynthetic gene clusters, achieves high precision and recall in genomic and metagenomic datasets, is extensively benchmarked and also experimentally verified: amazing new tool from Rob Finn MGnify EMBL-EBI biorxiv.org/content/10.110…

Check out our preprint on YeastIT, a new system for continuous evolution, addressing the challenge of biased mutational spectra and exploring the long-term evolutionary outcomes of different mutagenesis methods! biorxiv.org/content/10.110… Hollfelder Lab Matt Penner Philipp Knyphausen

Wonderful breakfast chat on scientific life in general with Frances Arnold, moderated by our researchers Lise Boursinhac, Josephin Holstein and Clara Munger. No doubt she has energy enough for a plenary talk this afternoon! engbio.cam.ac.uk/events/innovat…

Remkes Scheele et al. make a new reaction accessible to large scale screening by tuning a DNA-aptamer to provide a fluorogenic read-out: Ultrahigh Throughput Evolution of Tryptophan Synthase in Droplets via an Aptamer Sensor | ACS Catalysis pubs.acs.org/doi/10.1021/ac…

A massive thank you to Frances Arnold for visiting us last week and for delivering a wonderful Alkis Seraphim Lecture and taking part in special events for postgrads, postdocs and early PIs. Thanks to all from School of Biological Sciences who joined in a fantastic day of centenary celebration.

A Nature Biotechnology article by Hollfelder Lab, James Thaventhiran, markohyvonen bsky social, Cambridge Department of Medicine, Oxford Protein Informatics Group (OPIG) establishes new technology for finding therapeutic antibodies in response to infectious disease outbreaks faster, using anti-covid reagents as a showcase: bioc.cam.ac.uk/news/new-techn…

Thank you for continued wonderful collaboration(s)!

Our take on the future of enzyme discovery: On synergy between ultrahigh throughput screening and machine learning in biocatalyst engineering - now published in Faraday Discussions pubs.rsc.org/en/content/art…

🎉 The highly anticipated iDEC Festival 2024 is happening on October 26-27 in Cambridge! 📍 Three distinguished scholars will deliver lectures at the awards ceremony. Stay tuned! ✨ #iDEC #directedevolution