We prósent our analysis of The sequences of 150,119 genomes in the UK biobank biorxiv.org/content/10.110… deCODE genetics Patrick Sulem Hannes P Eggertsson Kristján Moore (Kris) ➡️ kristjanmoore.bsky.social Hannеs Hauswedell | mastodon.social/@__h2__ Hákon Jónsson

It’s not about the money

A double overtime drama, and it’s the underdogs stealing victory! Iceland 🇮🇸 come up with the win over 🇮🇹 Italy behind a DOMINANT Tryggvi Hlinsason (34 PTS, 21 REB, 5 BLK) performance! #FIBAWC | #WinForIceland

Our large study on the potential health sequelae of SARS-CoV-2 infection is now out as preprint, from deCODE genetics in Iceland #Covid_19 #LongCovid

Congrats to Alexandre Mebazaa & team on #STRONGHF open label multicenter RCT (n=1078) 📍Early clinic follow up + rapid uptitration of #GDMT following #HF #hospitalization ⬇️180d all cause ☠️ or HF 🏥 following HHF thelancet.com/journals/lance… #implementation

🚨#STRONG_HF #AHA22 Rapid GDMT titration in HFrEF led to improved clinical outcomes (QOL, NTproBNP and reduction in combined HF hosp and death). sciencedirect.com/science/articl…

With all the ASHG fun, I missed this cool GWAS of NAFLD from the deCODE when it came out. Here the authors report an interesting protective association between rare variants in MTARC1 (encodes a mitochondrial membrane protein) and NAFLD. nature.com/articles/s4158…

It doesn't matter if you wipe front to back or back to front. Sincerely, Your friendly neighborhood urologist.

📈NEW RESEARCH Communications Medicine – Holm, Ivarsdottir, Olafsdottir et al. find conventional routine clinical tests not informative in diagnosing #LongCOVID │Hilma Hólm nature.com/articles/s4385…

An important new paper on CHIP (clonal hematopoiesis): how common it is with advanced age, that it can be detected via whole genome sequencing, and the association with cardiovascular disease is questioned nature.com/articles/s4158… Nature Genetics

Check out this work by my deCODE genetics colleagues, Simon Stacey and Florian Zink, on clonal hematopoiesis that appeared in Nature Genetics today: nature.com/articles/s4158… They show that you can call CH based on a mutation "barcode" in the absence of a typical driver mutation.

A new study examines the relationship of pathogenic and likely pathogenic variants for which preventive or therapeutic measures are available to life span and specific causes of death. Read the full study results: nej.md/3swUQCR

Editorial: Ten Years of Incidental, Secondary, and Actionable Findings nej.md/49tdex5

Proud to announce that our study on actionable genotypes and their association with life span using WGS data from 57,933 Icelanders has been published in NEJM. Guðný Árnadóttir Rún Friðriksdóttir Hannes Helgason Patrick Sulem nej.md/3swUQCR 1/8

From deCODE: A rare missense mutation in MYH6 confers high risk of coarctation of the aorta x.com/biorxivpreprin…

Coding variants in RPL3L and MYZAP increase risk of atrial fibrillation. The link btw the mechanical and electrical function of the heart continues to strengthen #bioRxiv x.com/biorxivpreprin…

Rare SCARB1 mutations associate with high-density lipoprotein cholesterol but not with coronary artery disease | European Heart Journal | Oxford Academic academic.oup.com/eurheartj/adva…

A rare missense mutation p.Arg721Trp in the sarcomere gene MYH6 has a strong effect on the risk of aortic coarctation - this is the first mutation associated with non-familial or sporadic form of CoA at a population level bit.ly/2qivfts European Society of Cardiology #ESCCoT #openaccess