Horsager et al. present evidence for the existence of two subtypes of Parkinson's disease: 'brain-first', which starts in the brain and propagates downwards, and 'body-first', which originates in the ANS of the gut and spreads to the brain. bit.ly/34OaU59

What does a TEG do? A 🧵

“Once upon a time there was a superior division always supplying frontal lobe, inferior division going to temporal lobe, with either division achieving dominance by annexing parietal lobe” This classic #MCA story is a #FairyTale bit.ly/3iFjvwQ Neuroangio

The natural highways of the brain

Today the endothelin receptor antagonist clazosentan (Pilvaz) was approved in Japan based on 2 positive RCTs which showed reduced death or DCI from vasospasm. The first new approved medical therapy for #SAH in over 25 years! Well done Idorsia!

Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era nature.com/articles/s4158… Institute for Stroke and Cerebrovascular Diseases

If you are not following Casey Albin, MD for #neurocrit #MedEd , are you even on #Twitter?

❤️ this excellent figure depicting the variants of GBS:

"Apple AirPods sign" 56M.T2DM. P/W vertigo/vomit/ataxia 24 hrs. MR Day2. ? artefactual. Coronal DWI helped. Over 48 hours became quadriparetic. Repeat MR Day4. What is the anatomical site infarcted?  Which artery could have been the culprit?

#Ethiopia’s 1st #neurointerventional/ #Stroke program & 1st biplane cath lab suite is now operational!😊🙏🏽. Our recent patient,42 F w/ “thunderclap” headaches. CT w/ bleeding in the brain. DSA>diffuse cerebral vasospasm,likely RCVS,we started her on nimodipine. She’s doing great.

Endovascular Therapy for Acute Stroke with a Large Ischemic Region pubmed.ncbi.nlm.nih.gov/35138767/ Yes, it had higher ICH but rate of symptomatic hemorrhage (9% vs 5%) was similar! Impressive outcomes w/ mRS < 3 of 31% vs 13% in EVT vs medical management alone! #Wow #LVO #EVT

A few yrs ago we launched a cardio neuro program @WestchesterMed Sei Iwai Fawaz Al-Mufti, MD, FSVIN Stroke Rx & critical care together. It’s paying off. Nice story of one of our successes: acute trans catheter stroke intervention 👉 #PFO closure Tracey Milligan, MD, MS, FAAN, FANA, FAES youtu.be/5sEtWjfuFao

A newly discovered lymphatic-like membrane in the subarachnoid space is close to the brain, offering a potential new therapeutic target against traumatic brain injury and #Alzheimers: bit.ly/40m8q8h #neurotwitter #TBI American Academy of Neurology

#Stroke July Cover Figure: Global consensus finds that hemoglobin is a root trigger of multiple pathways to brain injury after SAH, which could be targeted with haptoglobin, and the field is ready for a Phase I trial. (1/2)