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Why inhibit only one KRAS mutant when you can inhibit multiple KRAS alterations at the same time. Our pan-KRAS inhibitor paper is out. nature.com/articles/s4158…

Our newest publication ChemBioChem: LpMip as a potential target for our FKBP inhibitors to act as anti-infectives against Legionella pneumophila. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

Yesterday we had the famous Chem Cup soccer tournament. In spite of lacking success for our Team we had a great day with many exciting matches!

Check out our recent publication about solfonimidamide containing FKBP ligands! pubs.acs.org/doi/10.1021/ja…

Yesterday the AK Hausch Skat Cup was held for the 7th time. ♣♥♠♦ 10 participants have provided an exciting tournament, the outcome of which was decided only after a close neck-and-neck race in the last game.🎖

Our PROXIDRUGS-supported MoProX team wins 2nd price at the TU Ideenwettbewerb 2023! Congratulations to Thomas, Johannes, Christian and Felix! #Clusters4Future PROXIDRUGS

Depressionen, Diabetes, Fettleibigkeit - dies kann durch Stress ausgelöst oder befördert werden. Forschende der #TUDa Structure based drug research @TUDarmstadt Centre for Synthetic Biology @TUDarmstadt zeigen in zwei aktuellen Veröffentlichungen neue Wege für die Behandlung von stressbedingten Erkrankungen auf. tu-darmstadt.de/universitaet/a…

Check out our recent publication: Discovery of a Potent PROTAC Enables Targeting of FKBP51’s Scaffolding Functions - Geiger - Angewandte Chemie International Edition - Wiley Online Library onlinelibrary.wiley.com/doi/abs/10.100…

Finally our paper in Nature Structural & Chemical Biology was published. doi.org/10.1038/s41594… Congratulations to Asat, Sarah, Martha and Thomas!

PhD positions available in Life Science Engineering, incl. in cutting edge drug discovery (e.g. see publications in NSMB and ACIE) Nat Struct Mol Biol (2023). doi.org/10.1038/s41594… and Angew. Chem. Int. Ed. 2023, e202309706. (onlinelibrary.wiley.com/doi/abs/10.100…)

Selective PROTAC-mediated FKBP51 degradation at Frontiers in Medicinal Chemistry conference in Munich!

We presented posters about FKBP12 based molecular glues targeting BRD4 and the potential of Macrocyclization to improve aqueous solubility at the FiMC conference in Munich.

Craig M. Crews, Professor für Molekular-, Zellulär- und Entwicklungsbiologie, Chemie und Pharmakologie an der Yale University, erhält für bahnbrechende Forschung den Preis der „Emanuel Merck Vorlesung“. Gefeiert wird das mit einer Veranstaltungsreihe: chemie.tu-darmstadt.de/aktuelles_chem…

Craig Crews was awarded the prestigious Emanuel Merck Lectureship award for his outstanding research especially on proximity-based drug modalities. He gave an exciting lecture about his research on PROTACs as part of the public ceremony.

Check out our recent publication: Structure‐Based Design of Ultrapotent Tricyclic Ligands for FK506‐Binding proteins - Krajczy - Chemistry – A European Journal - Wiley Online Library …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/ch… Congratulations to Patryk and all who have contributed!

Our newest Publikation in ChemMedChem! 1,4‐Pyrazolyl‐containing SAFit‐analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug‐like profile - Buffa - ChemMedChem - Wiley Online Library …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

Postdoc in Medicinal Chemistry & Molecular Glue discovery wanted! Combine advanced organic chemistry & cutting edge drug discovery in a vibrant, international team? Further infos: chemie.tu-darmstadt.de/hausch/group_m…

MC4DD: New EU consortium on drug discovery dedicated to macrocycles. 8 universities and 6 industry partner join forces to advance the science of macrocycles as drugs. More information: MC4DD.com

📢 Job opening at EPFL: We are looking to fill a Tenure Track Professor Position in Chemical Biology! Please RT. #chemicalbiology #chembio #chemjobs #chemtwitter epfl.ch/about/working/…

For all Macrocycle and Linker afficionados: Check out our perspective recently published in J Med Chem! 📢 The Missing Link(er): A Roadmap to Macrocyclization in Drug Discovery | Journal of Medicinal Chemistry pubs.acs.org/doi/abs/10.102…